DHRS2 Antibody - #DF3985
| Product: | DHRS2 Antibody |
| Catalog: | DF3985 |
| Description: | Rabbit polyclonal antibody to DHRS2 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Mol.Wt.: | 27 KD; 30kD(Calculated). |
| Uniprot: | Q13268 |
| RRID: | AB_2836345 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3985, RRID:AB_2836345.
Fold/Unfold
5430405K24Rik; Dehydrogenase/reductase (SDR family) member 2; Dehydrogenase/reductase member 2; Dehydrogenase/reductase SDR family member 2; Dehydrogenase/reductase SDR family member 2 mitochondria; Dicarbonyl reductase HEP27; Hep27; HEP27 protein; MGC143467; Protein D; SDR family member; SDR25C1; Short chain alcohol dehydrogenase family member; Short chain dehydrogenase/reductase family 25C member 1;
Immunogens
Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.
- Q13268 DHRS2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGENIAVAGYSTRL
PTMs - Q13268 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K31 | Ubiquitination | Uniprot | |
| K79 | Acetylation | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| K96 | Acetylation | Uniprot | |
| K206 | Acetylation | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| K219 | Acetylation | Uniprot | |
| K219 | Ubiquitination | Uniprot | |
| K224 | Acetylation | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| K234 | Ubiquitination | Uniprot |
Research Backgrounds
Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
Mitochondrion matrix. Nucleus.
Note: A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.
Directly interacts with MDM2; this interaction occurs in the nucleus and does not target DHRS2 to degradation.
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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