DSG2 Antibody - #DF3988

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Product: DSG2 Antibody
Catalog: DF3988
Description: Rabbit polyclonal antibody to DSG2
Application: WB IHC IF/ICC
Reactivity: Human, Mouse
Prediction: Pig, Horse, Dog
Mol.Wt.: 140 KD; 122kD(Calculated).
Uniprot: Q14126
RRID: AB_2836348

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(82%), Horse(82%), Dog(82%)
Clonality:
Polyclonal
Specificity:
DSG2 Antibody detects endogenous levels of total DSG2.
RRID:
AB_2836348
Cite Format: Affinity Biosciences Cat# DF3988, RRID:AB_2836348.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ARVC 10; ARVC10; ARVD 10; ARVD10; Cadherin family member 5; CDHF 5; CDHF5; CMD1BB; Desmoglein 2; Desmoglein-2; Desmoglein2; DSG 2; DSG2; DSG2_HUMAN; HDGC; HDGC included; Human Desmoglein colon; MGC117034; MGC117036; MGC117037;

Immunogens

Immunogen:
Uniprot:

Q14126(DSG2_HUMAN) >>Visit HPA database.

Gene(ID):
DSG2(1829)
Expression:
Q14126 DSG2_HUMAN:

All of the tissues tested and carcinomas.

Sequence:
MARSPGRAYALLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAGVPGPLPDFGLEESGHSNSTITTSSTRVTKHSTVQHSYS

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
82
Horse
82
Dog
82
Bovine
73
Sheep
73
Rabbit
64
Xenopus
60
Chicken
55
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q14126 As Substrate

Site PTM Type Enzyme
S4 Phosphorylation
S75 Phosphorylation
R81 Methylation
N112 N-Glycosylation
K141 Ubiquitination
N182 N-Glycosylation
Y207 Phosphorylation
Y212 Phosphorylation
Y221 Phosphorylation
Y235 Phosphorylation
T291 Phosphorylation
S363 Phosphorylation
R434 Methylation
N462 N-Glycosylation
T484 Phosphorylation
S551 Phosphorylation
T552 Phosphorylation
S559 Phosphorylation
K561 Ubiquitination
T645 Phosphorylation
T650 Phosphorylation
K667 Ubiquitination
S680 Phosphorylation
T695 Phosphorylation
K697 Methylation
K697 Ubiquitination
S699 Phosphorylation
S700 Phosphorylation
S701 Phosphorylation
S703 Phosphorylation
K706 Ubiquitination
S712 Phosphorylation
S723 Phosphorylation
S726 Phosphorylation
T733 Phosphorylation
T744 Phosphorylation
T745 Phosphorylation
K746 Ubiquitination
R773 Methylation
Y775 Phosphorylation
K779 Ubiquitination
S782 Phosphorylation
Y783 Phosphorylation
T791 Phosphorylation
T804 Phosphorylation
S806 Phosphorylation
S810 Phosphorylation
S815 Phosphorylation
K832 Ubiquitination
T835 Phosphorylation
K849 Ubiquitination
T874 Phosphorylation
T881 Phosphorylation
Y882 Phosphorylation
S884 Phosphorylation
S893 Phosphorylation
K901 Ubiquitination
T903 Phosphorylation
S911 Phosphorylation
T922 Phosphorylation
S939 Phosphorylation
T942 Phosphorylation
Y968 Phosphorylation
T973 Phosphorylation
Y979 Phosphorylation
T984 Phosphorylation
S999 Phosphorylation
Y1013 Phosphorylation
S1021 Phosphorylation
S1055 Phosphorylation
T1056 Phosphorylation
S1059 Phosphorylation
S1060 Phosphorylation
Y1061 Phosphorylation
S1093 Phosphorylation
S1098 Phosphorylation
T1099 Phosphorylation
K1109 Ubiquitination
S1111 Phosphorylation
Y1117 Phosphorylation
S1118 Phosphorylation

Research Backgrounds

Function:

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Subcellular Location:

Cell membrane>Single-pass type I membrane protein. Cell junction>Desmosome.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

All of the tissues tested and carcinomas.

Family&Domains:

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

Research Fields

· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).

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