HECW2 Antibody - #DF4018
| Product: | HECW2 Antibody |
| Catalog: | DF4018 |
| Description: | Rabbit polyclonal antibody to HECW2 |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Prediction: | Sheep, Rabbit |
| Mol.Wt.: | 140-150 KD; 176kD(Calculated). |
| Uniprot: | Q9P2P5 |
| RRID: | AB_2836378 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4018, RRID:AB_2836378.
Fold/Unfold
C2 and WW domain-containing protein 2; E3 ubiquitin protein ligase HECW2; E3 ubiquitin-protein ligase HECW2; HECT; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; Hecw2; HECW2_HUMAN; KIAA130; KIAA1301; NEDD4 like E3 ubiquitin protein ligase 2; NEDD4 Related E3 Ubiquitin Ligase; NEDD4-like E3 ubiquitin-protein ligase 2;
Immunogens
- Q9P2P5 HECW2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQSSMPENMTLQRANSDTDLVTSESRSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNPAVMMGAEGMEGGASGNLHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADHVSGYLQFKVEVTSSVHEDASPEAVGTILGVNSVNGDLGSPSDDEDMPGSHHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLEIDTEELTSTSSRTSPPRGRQDSLNDYLDAIEHNGHSRPGTATCSERSMGASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQQDLGYPSSLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKPENLPELAESSLPAGPAPEEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSETESLDQGSEPSQVSSETEPSDPARTESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRCSSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9P2P5 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| T50 | Phosphorylation | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K199 | Methylation | Uniprot | |
| Y208 | Phosphorylation | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| K218 | Ubiquitination | Uniprot | |
| S220 | Phosphorylation | Uniprot | |
| S390 | Phosphorylation | Uniprot | |
| T396 | Phosphorylation | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| T453 | Phosphorylation | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| S742 | Phosphorylation | Uniprot | |
| S850 | Phosphorylation | Uniprot | |
| S852 | Phosphorylation | Uniprot | |
| S865 | Phosphorylation | Uniprot | |
| S909 | Phosphorylation | Uniprot | |
| S1027 | Phosphorylation | Uniprot | |
| S1040 | Phosphorylation | Uniprot | |
| S1042 | Phosphorylation | Uniprot | |
| T1064 | Phosphorylation | Uniprot | |
| S1171 | Phosphorylation | Uniprot | |
| S1175 | Phosphorylation | Uniprot | |
| S1237 | Phosphorylation | Uniprot | |
| T1398 | Phosphorylation | Uniprot | |
| S1439 | Phosphorylation | Uniprot |
Research Backgrounds
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition.
Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1.
Cytoplasm. Cytoplasm>Cytoskeleton>Spindle.
Predominantly expressed in adult brain, lung and heart.
Interacts with TP73. Interacts with FZR1.
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