PTGR1 Antibody - #DF4216
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4216, RRID:AB_2836567.
Fold/Unfold
15-oxoprostaglandin 13-reductase; FLJ99229; leukotriene B4 12-hydroxydehydrogenase; LTB4DH; MGC34943; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; PGR1; PRG-1; Prostaglandin reductase 1; Ptgr1; PTGR1_HUMAN; RP11-16L21.1; ZADH3; zinc binding alcohol dehydrogenase domain containing 3;
Immunogens
- Q14914 PTGR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVRTKTWTLKKHFVGYPTNSDFELKTAELPPLKNGEVLLEALFLTVDPYMRVAAKRLKEGDTMMGQQVAKVVESKNVALPKGTIVLASPGWTTHSISDGKDLEKLLTEWPDTIPLSLALGTVGMPGLTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDEKVAYLQKLGFDVVFNYKTVESLEETLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIAICGAISTYNRTGPLPPGPPPEIVIYQELRMEAFVVYRWQGDARQKALKDLLKWVLEGKIQYKEYIIEGFENMPAAFMGMLKGDNLGKTIVKA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q14914 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K11 | Ubiquitination | Uniprot | |
| Y16 | Phosphorylation | Uniprot | |
| T18 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| T26 | Phosphorylation | Uniprot | |
| K58 | Ubiquitination | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| K100 | Acetylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| K231 | Acetylation | Uniprot | |
| K232 | Acetylation | Uniprot | |
| Y262 | Phosphorylation | Uniprot | |
| R280 | Methylation | Uniprot | |
| K289 | Acetylation | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| K324 | Ubiquitination | Uniprot |
Research Backgrounds
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.
Cytoplasm.
High expression in the kidney, liver, and intestine but not in leukocytes.
Monomer or homodimer.
Belongs to the NADP-dependent oxidoreductase L4BD family.
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