CHML Antibody - #DF4369
| Product: | CHML Antibody |
| Catalog: | DF4369 |
| Description: | Rabbit polyclonal antibody to CHML |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse |
| Mol.Wt.: | 85 KD; 74kD(Calculated). |
| Uniprot: | P26374 |
| RRID: | AB_2836657 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4369, RRID:AB_2836657.
Fold/Unfold
CHM like; Chml; Choroideraemia like protein; Choroideraemia-like protein; Choroideremia like (Rab escort protein 2); Choroideremia like; Choroideremia like protein; Rab escort protein 2; Rab proteins geranylgeranyltransferase component A 2; RAE2_HUMAN; REP 2; REP-2; REP2;
Immunogens
- P26374 RAE2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADNLPTEFDVVIIGTGLPESILAAACSRSGQRVLHIDSRSYYGGNWASFSFSGLLSWLKEYQQNNDIGEESTVVWQDLIHETEEAITLRKKDETIQHTEAFCYASQDMEDNVEEIGALQKNPSLGVSNTFTEVLDSALPEESQLSYFNSDEMPAKHTQKSDTEISLEVTDVEESVEKEKYCGDKTCMHTVSDKDGDKDESKSTVEDKADEPIRNRITYSQIVKEGRRFNIDLVSKLLYSQGLLIDLLIKSDVSRYVEFKNVTRILAFREGKVEQVPCSRADVFNSKELTMVEKRMLMKFLTFCLEYEQHPDEYQAFRQCSFSEYLKTKKLTPNLQHFVLHSIAMTSESSCTTIDGLNATKNFLQCLGRFGNTPFLFPLYGQGEIPQGFCRMCAVFGGIYCLRHKVQCFVVDKESGRCKAIIDHFGQRINAKYFIVEDSYLSEETCSNVQYKQISRAVLITDQSILKTDLDQQTSILIVPPAEPGACAVRVTELCSSTMTCMKDTYLVHLTCSSSKTAREDLESVVKKLFTPYTETEINEEELTKPRLLWALYFNMRDSSGISRSSYNGLPSNVYVCSGPDCGLGNEHAVKQAETLFQEIFPTEEFCPPPPNPEDIIFDGDDKQPEAPGTNNVVMAKLESSEESKNLESPEKHLQN
PTMs - P26374 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S161 | Phosphorylation | Uniprot | |
| S166 | Phosphorylation | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| T302 | Phosphorylation | Uniprot | |
| Y314 | Phosphorylation | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| K528 | Ubiquitination | Uniprot | |
| S641 | Phosphorylation | Uniprot | |
| S644 | Phosphorylation | Uniprot | |
| S649 | Phosphorylation | Uniprot |
Research Backgrounds
Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.
Cytoplasm>Cytosol.
Monomer. Heterotrimer composed of RABGGTA, RABGGTB and CHML; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHML (component A) mediates Rab protein binding. Interacts with RAB1A, RAB7A and RAB27A, but has much lower affinity for RAB1A, RAB7A and RAB27A than CHM. Interacts with the non-phosphorylated forms of RAB3A, RAB3B, RAB3C, RAB3D, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43.
Belongs to the Rab GDI family.
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