KCNK6 Antibody - #DF4310
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4310, RRID:AB_2836678.
Fold/Unfold
D7Ertd764e; FLJ12282; Inward rectifying potassium channel protein TWIK 2; Inward rectifying potassium channel protein TWIK-2; K2p6.1; K2P6.1 potassium channel; KCNK6; KCNK6_HUMAN; KCNK8; Potassium channel subfamily K member 6; Potassium channel, subfamily K, member 6 (TWIK 2); Potassium channel, subfamily K, member 6; TOSS; TWIK 2; TWIK 2 two pore domain K+ channel; TWIK originated sodium similarity sequence; TWIK-originated similarity sequence; TWIK2;
Immunogens
Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.
- Q9Y257 KCNK6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALDAFVERVLAAGRLGRVVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVVVTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTVYLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCPASFNADEDDRVDILGPQPESHQQLSASSHTDYASIPR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y257 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S51 | Phosphorylation | Uniprot |
Research Backgrounds
Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.
Membrane>Multi-pass membrane protein.
Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.
Homodimer.
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
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