PPM1L Antibody - #DF4349
| Product: | PPM1L Antibody |
| Catalog: | DF4349 |
| Description: | Rabbit polyclonal antibody to PPM1L |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| Mol.Wt.: | 48 KD; 41kD(Calculated). |
| Uniprot: | Q5SGD2 |
| RRID: | AB_2836717 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4349, RRID:AB_2836717.
Fold/Unfold
EC 3.1.3.16; in phosphatase 1 (formerly 2C) like; MGC132545; MGC132547; OTTHUMP00000213920; OTTHUMP00000213921; PP2C epsilon; PP2C-epsilon; PP2CE; PPM1 like; PPM1-LIKE; PPM1L; PPM1L_HUMAN; Protein phosphatase 1 (formerly 2C)-like; Protein phosphatase 1 like; Protein phosphatase 1-like; Protein phosphatase 1L; Protein phosphatase 2C epsilon isoform; Protein phosphatase 2C isoform epsilon; Protein phosphatase, Mg2+/Mn2+ dependent, 1L;
Immunogens
Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.
- Q5SGD2 PPM1L_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVKSSRDAVKMVKGKVAEIMQNDRLGGLDVLEAEFSKTWEFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q5SGD2 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K84 | Ubiquitination | Uniprot | |
| S187 | Phosphorylation | Uniprot | |
| Y188 | Phosphorylation | Uniprot |
Research Backgrounds
Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.
Membrane>Single-pass type I membrane protein.
Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.
Interacts with MAP3K7/TAK1 (By similarity). Interacts with MAP3K5.
Belongs to the PP2C family.
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