STK36 Antibody - #DF4465
| Product: | STK36 Antibody |
| Catalog: | DF4465 |
| Description: | Rabbit polyclonal antibody to STK36 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Dog |
| Mol.Wt.: | 170 KD; 144kD(Calculated). |
| Uniprot: | Q9NRP7 |
| RRID: | AB_2836820 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4465, RRID:AB_2836820.
Fold/Unfold
FU; Fused homolog; KIAA1278; Serine/threonine kinase 36, fused homolog; Serine/threonine protein kinase 36 fused homolog; Serine/threonine-protein kinase 36; STK36; STK36_HUMAN;
Immunogens
Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells.
- Q9NRP7 STK36_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILASELKSSWAKSGTGEVPSAPRENRTTPDCERAFPEERPEVLGQRSTDVVDLENEEPDSDNEWQHLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSSCSDSVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDLMAVIQAYFACTFNLERSQTSDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGNSRAISKAFYSSLLTTQQVVLDGLLHGLTVPQLPVHTPQGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYSCCLVSEGLCRLLGQEPLALESLFMLIQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGMEKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRLTPPGSCGFYDGLLILLLQLLTEQGKASLIRDMSSSEMWTVLWHRFSMVLRLPEEASAQEGELSLSSPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLRQAPHGSEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSDLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQHSMALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQAGIRRNVASALGNLGPEGLGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQEPGIHQVLVSLGASEKLSLLSLGNQSLPHSSPRPASAKHCRKLIHLLRPAHSM
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NRP7 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y19 | Phosphorylation | Uniprot | |
| Y25 | Phosphorylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| K37 | Acetylation | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| K317 | Ubiquitination | Uniprot | |
| T321 | Phosphorylation | Uniprot | |
| T331 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| K333 | Ubiquitination | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| K368 | Ubiquitination | Uniprot | |
| S578 | Phosphorylation | Uniprot | |
| T581 | Phosphorylation | Uniprot | |
| Y1181 | Phosphorylation | Uniprot | |
| K1250 | Ubiquitination | Uniprot | |
| S1288 | Phosphorylation | Uniprot | |
| S1293 | Phosphorylation | Uniprot | |
| S1314 | Phosphorylation | Uniprot |
Research Backgrounds
Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia.
Cytoplasm. Nucleus.
Note: Low levels also present in the nucleus.
Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells.
Interacts with GLI1, GLI2 and GLI3. Interacts with SPAG16 and KIF27.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
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