STAC2 Antibody - #DF4500

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Product: STAC2 Antibody
Catalog: DF4500
Description: Rabbit polyclonal antibody to STAC2
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 40 KD; 45kD(Calculated).
Uniprot: Q6ZMT1
RRID: AB_2836851

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(91%), Sheep(100%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
STAC2 Antibody detects endogenous levels of total STAC2.
RRID:
AB_2836851
Cite Format: Affinity Biosciences Cat# DF4500, RRID:AB_2836851.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

24b2; 24b2/STAC2; SH3 and cysteine rich domain 2; SH3 and cysteine rich domain containing protein 2; SH3 and cysteine-rich domain-containing protein 2; SRC homology 3 and cysteine rich domain protein 2; Src homology 3 and cysteine-rich domain-containing protein 2; STAC2; STAC2_HUMAN;

Immunogens

Immunogen:
Uniprot:

Q6ZMT1(STAC2_HUMAN) >>Visit HPA database.

Gene(ID):
STAC2(342667)
Sequence:
MTEMSEKENEPDDAATHSPPGTVSALQETKLQRFKRSLSLKTILRSKSLENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPSPCPVPRPLAALKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSFRRNFSSPLLVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Horse
91
Xenopus
64
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q6ZMT1 As Substrate

Site PTM Type Enzyme
S18 Phosphorylation
S39 Phosphorylation
S48 Phosphorylation
T72 Phosphorylation
S78 Phosphorylation
T90 Phosphorylation
S92 Phosphorylation
S94 Phosphorylation
S112 Phosphorylation
S122 Phosphorylation
S135 Phosphorylation
S174 Phosphorylation
S175 Phosphorylation
S192 Phosphorylation
S221 Phosphorylation
S224 Phosphorylation
T225 Phosphorylation
S228 Phosphorylation
S232 Phosphorylation
S234 Phosphorylation
T240 Phosphorylation
S246 Phosphorylation
S277 Phosphorylation
Y295 Phosphorylation
Y301 Phosphorylation
S372 Phosphorylation
T409 Phosphorylation

Research Backgrounds

Function:

Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.

Subcellular Location:

Cytoplasm>Cytosol. Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cell membrane>Sarcolemma>Peripheral membrane protein>Cytoplasmic side.
Note: Colocalizes with CACNA1C at the plasma membrane of transfected cells.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts (via SH3 domains) with CACNA1S. Interacts (via SH3 domains) with CACNA1C. Has much lower affinity for CACNA1C than for CACNA1S.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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