SH3RF3 Antibody - #DF4504
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4504, RRID:AB_2836855.
Fold/Unfold
Plenty of SH3s 2; POSH2; SH3 domain-containing RING finger protein 3; SH3 multiple domains protein 4; SH3MD4; SH3R3_HUMAN; SH3RF3;
Immunogens
- Q8TEJ3 SH3R3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLLGASWLCASKAAAAAAQSEGDEDRPGERRRRRAAATAAGAGEDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8TEJ3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T66 | Phosphorylation | Uniprot | |
| T67 | Phosphorylation | Uniprot | |
| S163 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| T383 | Phosphorylation | Uniprot | |
| S400 | Phosphorylation | Uniprot | |
| S412 | Phosphorylation | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| S438 | Phosphorylation | Uniprot | |
| T442 | Phosphorylation | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| T458 | Phosphorylation | Uniprot | |
| Y469 | Phosphorylation | Uniprot | |
| Y473 | Phosphorylation | Uniprot | |
| S542 | Phosphorylation | Uniprot | |
| T549 | Phosphorylation | Uniprot | |
| S558 | Phosphorylation | Uniprot | |
| T573 | Phosphorylation | Uniprot | |
| S731 | Phosphorylation | Uniprot | |
| T732 | Phosphorylation | Uniprot | |
| S736 | Phosphorylation | Uniprot | |
| S775 | Phosphorylation | Uniprot | |
| S797 | Phosphorylation | Uniprot | |
| S881 | Phosphorylation | Uniprot |
Research Backgrounds
Has E3 ubiquitin-protein ligase activity.
Autoubiquitinated.
Interacts (via SH3 domain 3) with PAK2. Interacts with RAC1 (GTP-bound form).
The RING finger domain is required for ubiquitin ligase activity and autoubiquitination.
Belongs to the SH3RF family.
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