SLC4A11 Antibody - #DF4511
| Product: | SLC4A11 Antibody |
| Catalog: | DF4511 |
| Description: | Rabbit polyclonal antibody to SLC4A11 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Mol.Wt.: | 100 KD; 100kD(Calculated). |
| Uniprot: | Q8NBS3 |
| RRID: | AB_2836862 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4511, RRID:AB_2836862.
Fold/Unfold
Bicarbonate transporter related protein 1; Bicarbonate transporter-related protein 1; BTR1; CDPD; CHED2; Corneal endothelial dystrophy 2 autosomal recessive; dJ794I6.2; FECD4; MGC126418; MGC126419; NaBC1; S4A11_HUMAN; Slc4a11; Sodium bicarbonate transporter-like protein 11; Sodium borate cotransporter 1; Sodium coupled borate cotransporter 1; Solute carrier family 4 member 11; Solute carrier family 4 sodium bicarbonate transporter like member 11; Solute carrier family 4 sodium borate transporter member 11;
Immunogens
Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes.
- Q8NBS3 S4A11_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSQVGGRGDRCTQEVQGLVHGAGDLSASLAENSPTMSQNGYFEDSSYYKCDTDDTFEAREEILGDEAFDTANSSIVSGESIRFFVNVNLEMQATNTENEATSGGCVLLHTSRKYLKLKNFKEEIRAHRDLDGFLAQASIVLNETATSLDNVLRTMLRRFARDPDNNEPNCNLDLLMAMLFTDAGAPMRGKVHLLSDTIQGVTATVTGVRYQQSWLCIICTMKALQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEALVHQRQLLTMVSHGPVAPRTKERSTVSLPAHRHPEPPKCKDFVPFGKGIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICDDYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKGTVKIFWKYYYGHYLDDYHTKRTSSLVSLSGLGASLNASLHTALNASFLASPTELPSATHSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVLAFSLISSHGFREIEMSKFRYNPSESPFAMAQIQSLSLRAVSGAMGLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPKPVLYGLFLYIALTSLDGNQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLLLLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRIIEAKYLDVMDAEHRP
PTMs - Q8NBS3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S74 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| T271 | Phosphorylation | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| T306 | Phosphorylation | Uniprot | |
| S309 | Phosphorylation | Uniprot | |
| T317 | Phosphorylation | Uniprot | |
| K344 | Ubiquitination | Uniprot | |
| K635 | Ubiquitination | Uniprot | |
| K752 | Ubiquitination | Uniprot | |
| K810 | Ubiquitination | Uniprot | |
| Y820 | Phosphorylation | Uniprot | |
| K880 | Ubiquitination | Uniprot |
Research Backgrounds
Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.
Glycosylated.
Cell membrane. Membrane>Multi-pass membrane protein.
Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes.
Homodimer.
Belongs to the anion exchanger (TC 2.A.31) family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.