SYTL4 Antibody - #DF4555

(3)  
Product: SYTL4 Antibody
Catalog: DF4555
Description: Rabbit polyclonal antibody to SYTL4
Application: WB IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
Mol.Wt.: 76 KD; 76kD(Calculated).
Uniprot: Q96C24
RRID: AB_2836906

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
SYTL4 Antibody detects endogenous levels of total SYTL4.
RRID:
AB_2836906
Cite Format: Affinity Biosciences Cat# DF4555, RRID:AB_2836906.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

DKFZp451P0116; Exophilin-2; FLJ40960; Granuphilin; SLP4; Synaptotagmin like 4; Synaptotagmin-like protein 4; Sytl4; SYTL4_HUMAN;

Immunogens

Immunogen:
Uniprot:

Q96C24(SYTL4_HUMAN) >>Visit HPA database.

Gene(ID):
SYTL4(94121)
Sequence:
MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYDQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPSVLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKETQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLRSSMAKQKLGL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Rabbit
100
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q96C24 As Substrate

Site PTM Type Enzyme
K47 Ubiquitination
S74 Phosphorylation
K123 Ubiquitination
R130 Methylation
S133 Phosphorylation
R137 Methylation
K177 Ubiquitination
S180 Phosphorylation
S199 Phosphorylation
S201 Phosphorylation
S204 Phosphorylation
T206 Phosphorylation
S213 Phosphorylation
S217 Phosphorylation
K220 Ubiquitination
S221 Phosphorylation
S231 Phosphorylation
S269 Phosphorylation
Y271 Phosphorylation
S274 Phosphorylation
S289 Phosphorylation
S294 Phosphorylation
S296 Phosphorylation
S340 Phosphorylation
Y345 Phosphorylation
Y366 Phosphorylation
Y396 Phosphorylation
S488 Phosphorylation
K510 Ubiquitination
T511 Phosphorylation
S520 Phosphorylation
T546 Phosphorylation
S547 Phosphorylation
Y554 Phosphorylation
S563 Phosphorylation
T567 Phosphorylation
Y649 Phosphorylation
S652 Phosphorylation
K666 Acetylation
K668 Acetylation

Research Backgrounds

Function:

Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).

Subcellular Location:

Membrane>Peripheral membrane protein. Cell membrane>Peripheral membrane protein. Cytoplasmic vesicle>Secretory vesicle membrane>Peripheral membrane protein.
Note: Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B. Interacts with MYO5A (By similarity).

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