TOR1AIP1 Antibody - #DF4568

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Product: TOR1AIP1 Antibody
Catalog: DF4568
Description: Rabbit polyclonal antibody to TOR1AIP1
Application: WB IF/ICC
Reactivity: Human
Prediction: Bovine, Horse, Sheep, Chicken
Mol.Wt.: 66 KD; 66kD(Calculated).
Uniprot: Q5JTV8
RRID: AB_2836919

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Bovine(89%), Horse(89%), Sheep(89%), Chicken(88%)
Clonality:
Polyclonal
Specificity:
TOR1AIP1 Antibody detects endogenous levels of total TOR1AIP1.
RRID:
AB_2836919
Cite Format: Affinity Biosciences Cat# DF4568, RRID:AB_2836919.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Lamin-associated protein 1B; Lamina associated polypeptide 1B; Lamina associated polypeptide 1C; LAP1; LAP1B; TOIP1_HUMAN; TOR1AIP1; Torsin A interacting protein 1; Torsin-1A-interacting protein 1;

Immunogens

Immunogen:
Uniprot:

Q5JTV8(TOIP1_HUMAN) >>Visit HPA database.

Gene(ID):
TOR1AIP1(26092)
Expression:
Q5JTV8 TOIP1_HUMAN:

Expressed in muscle, liver and kidney.

Sequence:
MAGDGRRAEAVREGWGVYVTPRAPIREGRGRLAPQNGGSSDAPAYRTPPSRQGRREVRFSDEPPEVYGDFEPLVAKERSPVGKRTRLEEFRSDSAKEEVRESAYYLRSRQRRQPRPQETEEMKTRRTTRLQQQHSEQPPLQPSPVMTRRGLRDSHSSEEDEASSQTDLSQTISKKTVRSIQEAPVSEDLVIRLRRPPLRYPRYEATSVQQKVNFSEEGETEEDDQDSSHSSVTTVKARSRDSDESGDKTTRSSSQYIESFWQSSQSQNFTAHDKQPSVLSSGYQKTPQEWAPQTARIRTRMQNDSILKSELGNQSPSTSSRQVTGQPQNASFVKRNRWWLLPLIAALASGSFWFFSTPEVETTAVQEFQNQMNQLKNKYQGQDEKLWKRSQTFLEKHLNSSHPRSQPAILLLTAARDAEEALRCLSEQIADAYSSFRSVRAIRIDGTDKATQDSDTVKLEVDQELSNGFKNGQNAAVVHRFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLGTSLGLKEVEEKVRDFLKVKFTNSNTPNSYNHMDPDKLNGLWSRISHLVLPVQPENALKRGICL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
89
Bovine
89
Sheep
89
Chicken
88
Pig
0
Dog
0
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q5JTV8 As Substrate

Site PTM Type Enzyme
T20 Phosphorylation
S39 Phosphorylation
T47 Phosphorylation
S50 Phosphorylation
S60 Phosphorylation
K76 Ubiquitination
S79 Phosphorylation
R115 Methylation
S135 Phosphorylation
S143 Phosphorylation P24941 (CDK2)
T147 Phosphorylation
S154 Phosphorylation
S156 Phosphorylation
S157 Phosphorylation
S163 Phosphorylation
S164 Phosphorylation
T166 Phosphorylation
S169 Phosphorylation
T171 Phosphorylation
K174 Ubiquitination
S179 Phosphorylation
S186 Phosphorylation
Y200 Phosphorylation
K211 Ubiquitination
S215 Phosphorylation
T220 Phosphorylation
S227 Phosphorylation
S228 Phosphorylation
S230 Phosphorylation
S231 Phosphorylation
T233 Phosphorylation
K236 Ubiquitination
S242 Phosphorylation
S245 Phosphorylation
T249 Phosphorylation
S252 Phosphorylation
S253 Phosphorylation
S254 Phosphorylation
Y256 Phosphorylation
S263 Phosphorylation
S266 Phosphorylation
K274 Ubiquitination
S277 Phosphorylation
S280 Phosphorylation
S281 Phosphorylation
K285 Ubiquitination
T286 Phosphorylation
T294 Phosphorylation
R300 Methylation
S305 Phosphorylation
K308 Ubiquitination
S309 Phosphorylation
S315 Phosphorylation
S317 Phosphorylation
S320 Phosphorylation
T324 Phosphorylation
K334 Ubiquitination
Y379 Phosphorylation
K385 Ubiquitination
N399 N-Glycosylation
S405 Phosphorylation
S466 Phosphorylation
K539 Ubiquitination
K556 Ubiquitination
K578 Ubiquitination

Research Backgrounds

Function:

Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.

Subcellular Location:

Nucleus inner membrane>Single-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in muscle, liver and kidney.

Subunit Structure:

Interacts with ATP1B4. Interacts with TOR1A (ATP-bound). Interacts with TOR1B, TOR2A and TOR3A. Interacts with VIM.

Family&Domains:

Belongs to the TOR1AIP family.

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