MOX2R Antibody | Affinity Biosciences

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Product:	MOX2R Antibody
Catalog:	DF4715
Description:	Rabbit polyclonal antibody to MOX2R
Application:	WB IF/ICC
Cited expt.:	WB
Reactivity:	Human
Mol.Wt.:	37 KD; 37kD(Calculated).
Uniprot:	Q8TD46
RRID:	AB_2837066

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Secondary Antibodies
Blocking Peptides

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific.

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100ul	$280	In stock
200ul	$350	In stock

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Related Downloads

MS Report

HPLC Report

MSDS

Data Sheet

COA

Protocols

WB Handbook

IHC Protocol

IF/ICC Protocol

Product Info

Source:

Rabbit

Application:

WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:

Human

Clonality:

Polyclonal

Specificity:

MOX2R Antibody detects endogenous levels of total MOX2R.

RRID:

AB_2837066
Cite Format: Affinity Biosciences Cat# DF4715, RRID:AB_2837066.

Conjugate:

Unconjugated.

Purification:

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Storage:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Alias:

Fold/Unfold

CD 200R; CD200 cell surface glycoprotein receptor; CD200 receptor 1; Cd200r1; Cell surface glycoprotein CD200 receptor 1; Cell surface glycoprotein OX2 receptor 1; Cell surface glycoprotein OX2 receptor; cell surface glycoprotein receptor CD200; CRTR 2; CRTR2; HCRTR2; MO2R1_HUMAN; MOX2 receptor; MOX2R; OX2R;

Immunogens

Immunogen:

A synthesized peptide derived from human MOX2R, corresponding to a region within C-terminal amino acids.

Uniprot:

Q8TD46(MO2R1_HUMAN) >>Visit HPA database.

Gene(ID):

CD200R1(131450)

Expression:

Q8TD46 MO2R1_HUMAN:

Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.

Sequence:

Q8TD46 MO2R1_HUMAN:
Protein BLAST With
NCBI/
ExPASy/
Uniprot

MLCPWRTANLGLLLILTIFLVAASSSLCMDEKQITQNYSKVLAEVNTSWPVKMATNAVLCCPPIALRNLIIITWEIILRGQPSCTKAYRKETNETKETNCTDERITWVSRPDQNSDLQIRPVAITHDGYYRCIMVTPDGNFHRGYHLQVLVTPEVTLFQNRNRTAVCKAVAGKPAAQISWIPEGDCATKQEYWSNGTVTVKSTCHWEVHNVSTVTCHVSHLTGNKSLYIELLPVPGAKKSAKLYIPYIILTIIILTIVGFIWLLKVNGCRKYKLNKTESTPVVEEDEMQPYASYTEKNNPLYDTTNKVKASEALQSEVDTDLHTL

Research Backgrounds

Q8TD46_MO2R1_HUMAN

Function:

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.

PTMs:

The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.

Subcellular Location:

Cell membrane>Single-pass type I membrane protein.

Cell membrane>Single-pass type I membrane protein.

Secreted.

Secreted.

Tissue Specificity:

Family&Domains:

Belongs to the CD200R family.

References

1). CD200-CD200R affects cisplatin and paclitaxel sensitivity by regulating cathepsin K-mediated p65 NF-κB signaling in cervical cancer. Heliyon, 2023 (PubMed: 37654464) [IF=4.0]

Application: WB Species: human Sample: THP-1 cells

Fig. 3 Effects of M2 macrophage-like THP-1 cells on invasion of HeLa and Siha cells. The expression of CD68 and CD163 was measured in THP-1 cells by flow cytometry (A) and Western blot (B). Expression of CD200R protein was measured in THP-1 cells by Western blotting (B). The full length of blots was provided in Supplemental materials. (C) Schematic diagram shows a coculture system of M2 macrophage-like THP-1 cells and cancer cells. (D) Cell invasion was measured by Transwell assay. The images of Transwell assay were provided in Supplemental Fig. 5. **P < 0.01.

Application: IHC Species: human Sample:

Fig. 8 Expression of CD200R and CTSK in tumor tissues from xenografts. Positive expression of CD200R (A) and CTSK (B) was analyzed by immunohistochemistry. Scale = 50 μm *P < 0.05, **P < 0.01.

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For Research Use Only.
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MOX2R Antibody - #DF4715