INA Antibody - #DF4833
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4833, RRID:AB_2837198.
Fold/Unfold
66 kDa neurofilament protein; AINX_HUMAN; Alpha Inx; Alpha-internexin; Alpha-Inx; INA; Internexin neuronal intermediate filament protein alpha; MGC12702; NEF 5; NEF5; Neurofilament 5 (66kD); Neurofilament 5; Neurofilament 66; Neurofilament 66 tax binding protein; Neurofilament-66; NF 66; NF-66; NF66; TXBP 1; TXBP1;
Immunogens
- Q16352 AINX_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSFGSEHYLCSSSSYRKVFGDGSRLSARLSGAGGAGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEEASKVASKKTSQIGESFEEILEETVISTKKTEKSNIEETTISSQKI
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16352 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S23 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| R104 | Methylation | Uniprot | |
| Y272 | Phosphorylation | Uniprot | |
| Y287 | Phosphorylation | Uniprot | |
| K290 | Acetylation | Uniprot | |
| K290 | Ubiquitination | Uniprot | |
| S335 | Phosphorylation | Uniprot | |
| R377 | Methylation | Uniprot | |
| Y379 | Phosphorylation | Uniprot | |
| Y396 | Phosphorylation | Uniprot | |
| T442 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| T463 | Phosphorylation | Uniprot | |
| K483 | Acetylation | Uniprot | |
| S496 | Phosphorylation | Uniprot | |
| K498 | Acetylation | Uniprot |
Research Backgrounds
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.
O-glycosylated.
Found predominantly in adult CNS.
Belongs to the intermediate filament family.
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