ETBR2 Antibody - #DF4926
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*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4926, RRID:AB_2837279.
Fold/Unfold
Endothelin B Receptor Like Protein 2; Endothelin B receptor-like protein 2; ETBR LP 2; ETBR-LP-2; ETBR2_HUMAN; ETBRLP2; G protein coupled receptor 37 like 1; G-protein coupled receptor 37-like 1; Gpr37l1;
Immunogens
Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594). Expressed in the central nervous system (PubMed:9539149).
- O60883 G37L1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRWLWPLAVSLAVILAVGLSRVSGGAPLHLGRHRAETQEQQSRSKRGTEDEEAKGVQQYVPEEWAEYPRPIHPAGLQPTKPLVATSPNPGKDGGTPDSGQELRGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAPTMGTLDSCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKSECRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTPC
PTMs - O60883 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T48 | Phosphorylation | Uniprot | |
| T79 | O-Glycosylation | Uniprot | |
| T85 | O-Glycosylation | Uniprot | |
| S86 | O-Glycosylation | Uniprot | |
| T95 | O-Glycosylation | Uniprot | |
| T107 | O-Glycosylation | Uniprot | |
| S247 | Phosphorylation | Uniprot | |
| T393 | Phosphorylation | Uniprot | |
| S404 | Phosphorylation | Uniprot | |
| T405 | Phosphorylation | Uniprot |
Research Backgrounds
G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).
O-glycosylated.
Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity.
Ubiquitinated.
Cell membrane>Multi-pass membrane protein. Cell projection>Cilium membrane>Multi-pass membrane protein.
Note: Associates with the basal membrane of Bergmann glia cell primary cilia.
Expressed in primary cortical astrocytes (at protein level). Expressed in the central nervous system.
Interacts with the PTCH1 receptor.
The N-terminal region is required for constitutive signal transduction.
Belongs to the G-protein coupled receptor 1 family.
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