GPR114 Antibody - #DF4942
| Product: | GPR114 Antibody |
| Catalog: | DF4942 |
| Description: | Rabbit polyclonal antibody to GPR114 |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Mol.Wt.: | 59 KD; 59kD(Calculated). |
| Uniprot: | Q8IZF4 |
| RRID: | AB_2837295 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4942, RRID:AB_2837295.
Fold/Unfold
ADGRG5; Adhesion G-protein coupled receptor G5; AGRG5_HUMAN; G protein coupled receptor 114; G-protein coupled receptor 114; G-protein coupled receptor PGR27; PGR27;
Immunogens
Expressed in immune cells. Primarily found in granulocytes. Found in eosinophils.
- Q8IZF4 AGRG5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDHCGALFLCLCLLTLQNATTETWEELLSYMENMQVSRGRSSVFSSRQLHQLEQMLLNTSFPGYNLTLQTPTIQSLAFKLSCDFSGLSLTSATLKRVPQAGGQHARGQHAMQFPAELTRDACKTRPRELRLICIYFSNTHFFKDENNSSLLNNYVLGAQLSHGHVNNLRDPVNISFWHNQSLEGYTLTCVFWKEGARKQPWGGWSPEGCRTEQPSHSQVLCRCNHLTYFAVLMQLSPALVPAELLAPLTYISLVGCSISIVASLITVLLHFHFRKQSDSLTRIHMNLHASVLLLNIAFLLSPAFAMSPVPGSACTALAAALHYALLSCLTWMAIEGFNLYLLLGRVYNIYIRRYVFKLGVLGWGAPALLVLLSLSVKSSVYGPCTIPVFDSWENGTGFQNMSICWVRSPVVHSVLVMGYGGLTSLFNLVVLAWALWTLRRLRERADAPSVRACHDTVTVLGLTVLLGTTWALAFFSFGVFLLPQLFLFTILNSLYGFFLFLWFCSQRCRSEAEAKAQIEAFSSSQTTQ
PTMs - Q8IZF4 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S524 | Phosphorylation | Uniprot | |
| T527 | Phosphorylation | Uniprot |
Research Backgrounds
Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking).
Autoproteolysis between residues Leu-226 and Thr-227 occurs in the lumen of the endoplasmic reticulum during receptor biosynthesis. The N-terminal fragment (NTF) subsequently reassociates with the C-terminal fragment (CTF) either in a homogeneric heterodimerization, or with another family member through heterogeneric heterodimerization. Autocatalytic cleavage is thought to be critical for the maturation, stability, trafficking, and function.
Cell membrane>Multi-pass membrane protein.
Expressed in immune cells. Primarily found in granulocytes. Found in eosinophils.
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
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