FAST kinase Antibody - #AF5115
| Product: | FAST kinase Antibody |
| Catalog: | AF5115 |
| Description: | Rabbit polyclonal antibody to FAST kinase |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 61 kDa; 61kD(Calculated). |
| Uniprot: | Q14296 |
| RRID: | AB_2837601 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF5115, RRID:AB_2837601.
Fold/Unfold
Fas activated serine threonine kinase; Fas-activated serine/threonine kinase; FAST; FAST kinase; FASTK; FASTK_HUMAN; FLJ13079;
Immunogens
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
- Q14296 FASTK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQPCCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQERRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q14296 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S41 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| K402 | Ubiquitination | Uniprot | |
| K417 | Ubiquitination | Uniprot | |
| S497 | Phosphorylation | Uniprot | |
| K530 | Ubiquitination | Uniprot |
Research Backgrounds
Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.
Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.
Autophosphorylated on serine/threonine residues. Activated by dephosphorylation.
Mitochondrion matrix.
Note: Colocalizes with mitochondrial RNA granules.
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Interacts with TIA-1 and TIAR.
The RAP domain is essential for RNA-binding.
Belongs to the FAST protein kinase family.
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