Annexin III Antibody - #AF5159

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Product: Annexin III Antibody
Catalog: AF5159
Description: Rabbit polyclonal antibody to Annexin III
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
Mol.Wt.: 36 kDa; 36kD(Calculated).
Uniprot: P12429
RRID: AB_2837645

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Bovine(100%), Horse(90%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
Annexin III Antibody detects endogenous levels of total Annexin III.
RRID:
AB_2837645
Cite Format: Affinity Biosciences Cat# AF5159, RRID:AB_2837645.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

2-cyclic phosphate 2-phosphohydrolase; 35-alpha calcimedin; Annexin A3; Annexin III; Annexin-3; ANX3; ANXA 3; Anxa3; ANXA3_HUMAN; Calcimedin 35 alpha; Inositol 1 2 cyclic phosphate 2 phosphohydrolase; Inositol 1; Lipocortin III; OTTHUMP00000160701; OTTHUMP00000219237; OTTHUMP00000219238; PAP III; PAP-III; Placental anticoagulant protein III;

Immunogens

Immunogen:
Uniprot:

P12429(ANXA3_HUMAN) >>Visit HPA database.

Gene(ID):
ANXA3(306)
Description:
Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
Sequence:
MASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKICGGDD

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Rabbit
100
Horse
90
Pig
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P12429 As Substrate

Site PTM Type Enzyme
Y15 Phosphorylation
S19 Phosphorylation
K29 Acetylation
K29 Ubiquitination
K58 Acetylation
K58 Ubiquitination
K66 Ubiquitination
T89 Phosphorylation
K97 Acetylation
K104 Methylation
K104 Ubiquitination
Y132 Phosphorylation
K137 Acetylation
K138 Ubiquitination
S139 Phosphorylation
S146 Phosphorylation
T148 Phosphorylation
S149 Phosphorylation
K154 Ubiquitination
S167 Phosphorylation
K169 Acetylation
K169 Ubiquitination
K176 Ubiquitination
K184 Ubiquitination
K196 Ubiquitination
K210 Ubiquitination
Y216 Phosphorylation
K222 Acetylation
K222 Ubiquitination
K263 Acetylation
K263 Ubiquitination
S280 Phosphorylation
Y295 Phosphorylation
Y297 Phosphorylation
Y300 Phosphorylation
S301 Phosphorylation
S308 Phosphorylation
Y311 Phosphorylation

Research Backgrounds

Function:

Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

Family&Domains:

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Belongs to the annexin family.

References

1). ANXA3 as a novel biomarker for sepsis diagnosis: Evidence from integrative WGCNA analysis. Heliyon, 2024 (PubMed: 39430518) [IF=4.0]
2). ANXA3 interference inactivates ERK/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury. Molecular immunology, 2024 (PubMed: 38310670) [IF=3.2]

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