Phospho-Cyclin C (Ser275) Antibody - #AF5435
| Product: | Phospho-Cyclin C (Ser275) Antibody |
| Catalog: | AF5435 |
| Description: | Rabbit polyclonal antibody to Phospho-Cyclin C (Ser275) |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus |
| Mol.Wt.: | 33 kDa; 33kD(Calculated). |
| Uniprot: | P24863 |
| RRID: | AB_2837919 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF5435, RRID:AB_2837919.
Fold/Unfold
ccnc; CCNC_HUMAN; CycC; Cyclin C; Cyclin-C; hSRB11; OTTHUMP00000016897; SRB11 homolog;
Immunogens
A synthesized peptide derived from human Cyclin C around the phosphorylation site of Ser275.
Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
- P24863 CCNC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
Research Backgrounds
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Nucleus.
Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
Belongs to the cyclin family. Cyclin C subfamily.
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