NUDT6 Antibody - #DF6063

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Product: NUDT6 Antibody
Catalog: DF6063
Description: Rabbit polyclonal antibody to NUDT6
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 36kDa; 36kD(Calculated).
Uniprot: P53370
RRID: AB_2838032

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Zebrafish(83%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
NUDT6 Antibody detects endogenous levels of total NUDT6.
RRID:
AB_2838032
Cite Format: Affinity Biosciences Cat# DF6063, RRID:AB_2838032.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Antisense basic fibroblast growth factor; FGF2AS; GFG1; Nucleoside diphosphate linked moiety X motif 6; Nucleoside diphosphate-linked moiety X motif 6; Nudix motif 6; NUDT6; NUDT6_HUMAN; Protein GFG;

Immunogens

Immunogen:
Uniprot:

P53370(NUDT6_HUMAN) >>Visit HPA database.

Gene(ID):
NUDT6(11162)
Expression:
P53370 NUDT6_HUMAN:

Detected in liver, kidney and esophagus (at protein level). Ubiquitous.

Description:
NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6), also known as Antisense basic fibroblast growth factor or GFG-1, is a member of the Nudix hydrolase family of pyrophosphatases. Nudix hydrolases contain a characteristic Nudix domain and are responsible for catalyzing the hydrolysis of nucleoside diphosphate derivatives. The gene encoding NUDT6 is a FGF-2 gene antisense transcript, and NUDT6 is believed to regulate FGF-2 expression. FGF-2 is a mutifunctional heparin-binding growth factor important to angiogenesis, neuroectoderm development and wound healing. NUDT6 is expressed as two isoforms produced by alternative splicing.
Sequence:
MRQPLSWGRWRAMLARTYGPGPSAGYRWASGAQGYVRNPPVGACDLQGELDRFGGISVRLARLDALDRLDAAAFQKGLQAAVQQWRSEGRTAVWLHIPILQSRFIAPAASLGFCFHHAESDSSTLTLWLREGPSRLPGYASHQVGVAGAVFDESTRKILVVQDRNKLKNMWKFPGGLSEPEEDIGDTAVREVFEETGIKSEFRSVLSIRQQHTNPGAFGKSDMYIICRLKPYSFTINFCQEECLRCEWMDLNDLAKTENTTPITSRVARLLLYGYREGFDKIDLTVEELPAVYTGLFYKLYHKELPENYKTMKGID

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Zebrafish
83
Xenopus
75
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P53370 As Substrate

Site PTM Type Enzyme
S57 Phosphorylation
K76 Ubiquitination
K303 Ubiquitination

Research Backgrounds

Function:

May contribute to the regulation of cell proliferation.

Subcellular Location:

Cytoplasm. Nucleus. Mitochondrion.
Note: Subcellular location may vary between isoforms.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Detected in liver, kidney and esophagus (at protein level). Ubiquitous.

Subunit Structure:

Monomer and homodimer.

Family&Domains:

Belongs to the Nudix hydrolase family.

Restrictive clause

 

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