TREM1 Antibody - #DF6091
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF6091, RRID:AB_2838059.
Fold/Unfold
CD354; OTTMUSP00000018206; TREM 1; TREM-1; TREM1; TREM1_HUMAN; Triggering receptor expressed on monocytes 1; Triggering receptor expressed on myeloid cells 1; Triggering receptor TREM 1; Triggering receptor TREM1;
Immunogens
Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.
- Q9NP99 TREM1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRKTRLWGLLWMLFVSELRAATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP
PTMs - Q9NP99 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T66 | Phosphorylation | Uniprot | |
| T70 | Phosphorylation | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| K120 | Ubiquitination | Uniprot | |
| T140 | Phosphorylation | Uniprot | |
| S143 | Phosphorylation | Uniprot |
Research Backgrounds
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
Glycosylated.
Cell membrane>Single-pass type I membrane protein.
Secreted.
Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.
Interacts with TYROBP/DAP12.
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