DEFB121 Antibody - #DF6340
(2)
| Product: | DEFB121 Antibody |
| Catalog: | DF6340 |
| Description: | Rabbit polyclonal antibody to DEFB121 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human |
| Mol.Wt.: | 8kDa; 8kD(Calculated). |
| Uniprot: | Q5J5C9 |
| RRID: | AB_2838304 |
Related Downloads
Protocols
Product Info
Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Reactivity:
Human
Clonality:
Polyclonal
Specificity:
DEFB121 Antibody detects endogenous levels of total DEFB121.
RRID:
AB_2838304
Cite Format: Affinity Biosciences Cat# DF6340, RRID:AB_2838304.
Cite Format: Affinity Biosciences Cat# DF6340, RRID:AB_2838304.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Immunogens
Immunogen:
Uniprot:
Gene(ID):
Expression:
Description:
∫-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, ∫-defensins are developmentally regulated. The family of ∫-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many ∫-defensins also are involved in sperm maturation and capacitation. ∫-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, ∫-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other ∫-defensins, it does not appear to be regulated by androgens.
Sequence:
- Q5J5C9 DB121_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKLLLLLLTVTLLLAQVTPVMKCWGKSGRCRTTCKESEVYYILCKTEAKCCVDPKYVPVKPKLTDTNTSLESTSAV
PTMs - Q5J5C9 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T18 | Phosphorylation | Uniprot |
Research Backgrounds
Function:
Has antibacterial activity.
Subcellular Location:
Secreted.
Tissue Specificity:
Abundant expression in the male reproductive tract only.
Family&Domains:
Belongs to the beta-defensin family.
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For Research Use Only.
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