ORM1 Antibody - #DF6623

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Product: ORM1 Antibody
Catalog: DF6623
Description: Rabbit polyclonal antibody to ORM1
Application: WB IHC
Reactivity: Human, Mouse
Mol.Wt.: 24kDa; 24kD(Calculated).
Uniprot: P02763
RRID: AB_2838585

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
ORM1 Antibody detects endogenous levels of total ORM1.
RRID:
AB_2838585
Cite Format: Affinity Biosciences Cat# DF6623, RRID:AB_2838585.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

A1AG1_HUMAN; AGP 1; AGP A; AGP; AGP1; Alpha 1 acid glycoprotein; Alpha-1-acid glycoprotein 1; alpha-1-AGP; Epididymis secretory sperm binding protein Li 153w; glycoprotein, alpha-1-acid, of serum; HEL S 153w; OMD 1; ORM; ORM1; Orosomucoid 1; Orosomucoid-1;

Immunogens

Immunogen:
Uniprot:

P02763(A1AG1_HUMAN) >>Visit HPA database.

Gene(ID):
ORM1(5004)
Expression:
P02763 A1AG1_HUMAN:

Expressed by the liver and secreted in plasma.

Description:
Alpha-1-acid glycoprotein 1 (AGP1), also called orosomucoid-1 (ORM1), is a glycoprotein synthesized mostly by hepatocytes and present in human plasma. ORM1 is an acute-phase reactant protein controlled by glucocorticoids, interleukin-1 and interleukin-6, and increase up to 5-50 times upon infection and/or inflammation. Anti-apoptotic effect and role as immunomodulator of ORM have been reported. ORM is an important carrier for synthetic drugs and influences their distribution and availability in the body. This antibody recognizes a band about 44 kDa in human plasma which may be due to the glycosylation of ORM1 or the dimer formation of the protein.
Sequence:
MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDQITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQDQCIYNTTYLNVQRENGTISRYVGGQEHFAHLLILRDTKTYMLAFDVNDEKNWGLSVYADKPETTKEQLGEFYEALDCLRIPKSDVVYTDWKKDKCEPLEKQHEKERKQEEGES

PTMs - P02763 As Substrate

Site PTM Type Enzyme
N33 N-Glycosylation
N56 N-Glycosylation
N72 N-Glycosylation
N93 N-Glycosylation
Y109 Phosphorylation
Y175 Phosphorylation
K179 Acetylation

Research Backgrounds

Function:

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

PTMs:

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed by the liver and secreted in plasma.

Family&Domains:

Contains a beta-barrel that binds various ligands in its interior.

Belongs to the calycin superfamily. Lipocalin family.

References

1). iTRAQ based proteomic analysis of PM2.5 induced lung damage. RSC Advances, 2019 (PubMed: 35517034) [IF=3.9]

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