PDCD10 Antibody - #DF7080
| Product: | PDCD10 Antibody |
| Catalog: | DF7080 |
| Description: | Rabbit polyclonal antibody to PDCD10 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus |
| Mol.Wt.: | 25kDa; 25kD(Calculated). |
| Uniprot: | Q9BUL8 |
| RRID: | AB_2839036 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF7080, RRID:AB_2839036.
Fold/Unfold
Apoptosis related protein 15; CCM3; Cerebral cavernous malformations 3 protein; MGC1212; MGC24477; PDC10_HUMAN; PDCD 10; PDCD10; Programmed cell death 10; Programmed cell death protein 10; TF 1 cell apoptosis related protein 15; TF-1 cell apoptosis-related protein 15; TFAR15;
Immunogens
- Q9BUL8 PDC10_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRMTMEEMKNEAETTSMVSMPLYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKILEKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFVSANRLIHQTNLILQTFKTVA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BUL8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S39 | Phosphorylation | O00506 (STK25) , Q9P289 (STK26) | Uniprot |
| T43 | Phosphorylation | Q9P289 (STK26) , O00506 (STK25) | Uniprot |
| K50 | Ubiquitination | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| K116 | Ubiquitination | Uniprot | |
| R124 | Methylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| K172 | Ubiquitination | Uniprot | |
| K179 | Acetylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| T201 | Phosphorylation | Uniprot |
Research Backgrounds
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).
Cytoplasm. Golgi apparatus membrane>Peripheral membrane protein>Cytoplasmic side. Cell membrane>Peripheral membrane protein>Cytoplasmic side.
Note: Partially co-localizes with endogenous PXN at the leading edges of migrating cells.
Ubiquitous.
Homodimer. Interacts (via C-terminus) with CCM2. Interacts (via C-terminus) with PXN. Interacts (via N-terminus) with STK25. Interacts (via N-terminus) with STK26. Interacts (via N-terminus) with STK24. Interacts with GOLGA2. Identified in a complex with KRIT1 and CCM2. Interacts with KDR/VEGFR2. Interaction with KDR/VEGFR2 is enhanced by stimulation with VEGFA (By similarity). Interacts with RIPOR1 (via C-terminus); this interaction is required for the association of RIPOR1 with either STK24 and STK26 kinases and occurs in a Rho-independent manner.
Belongs to the PDCD10 family.
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