KLK5 Antibody - #DF7137

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Product: KLK5 Antibody
Catalog: DF7137
Description: Rabbit polyclonal antibody to KLK5
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 32kDa; 32kD(Calculated).
Uniprot: Q9Y337
RRID: AB_2839091

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:100-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(80%), Bovine(90%), Horse(80%), Sheep(90%), Rabbit(100%), Dog(90%)
Clonality:
Polyclonal
Specificity:
KLK5 Antibody detects endogenous levels of total KLK5.
RRID:
AB_2839091
Cite Format: Affinity Biosciences Cat# DF7137, RRID:AB_2839091.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

HK5; Kallikrein 5; Kallikrein L2; Kallikrein like 2; Kallikrein like protein 2; Kallikrein related peptidase 5; Kallikrein-5; Kallikrein-like protein 2; Kallikrein5; KLK 5; KLK L2; KLK-L2; KLK5; KLK5_HUMAN; KLKL 2; KLKL2; SCTE; Stratum corneum tryptic enzyme; UNQ570/PRO1132;

Immunogens

Immunogen:
Uniprot:

Q9Y337(KLK5_HUMAN) >>Visit HPA database.

Gene(ID):
KLK5(25818)
Expression:
Q9Y337 KLK5_HUMAN:

Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin.

Description:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein.
Sequence:
MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Bovine
90
Sheep
90
Dog
90
Pig
80
Horse
80
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9Y337 As Substrate

Site PTM Type Enzyme
N208 N-Glycosylation
S213 Phosphorylation

Research Backgrounds

Function:

May be involved in desquamation.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin.

Subunit Structure:

Interacts with SPINK9.

Family&Domains:

Belongs to the peptidase S1 family. Kallikrein subfamily.

Restrictive clause

 

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