AZGP1 Antibody - #DF7304

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Product: AZGP1 Antibody
Catalog: DF7304
Description: Rabbit polyclonal antibody to AZGP1
Application: WB IHC
Reactivity: Human, Mouse
Prediction: Rabbit
Mol.Wt.: 34kDa; 34kD(Calculated).
Uniprot: P25311
RRID: AB_2839242

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Rabbit(82%)
Clonality:
Polyclonal
Specificity:
AZGP1 Antibody detects endogenous levels of total AZGP1.
RRID:
AB_2839242
Cite Format: Affinity Biosciences Cat# DF7304, RRID:AB_2839242.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Alpha 2 glycoprotein 1 zinc; Alpha 2 glycoprotein 1 zinc binding; Alpha 2 glycoprotein zinc; Azgp1; ZA2G; ZA2G_HUMAN; ZAG; Zinc alpha 2 glycoprotein precursor; Zinc-alpha-2-glycoprotein; Zn alpha 2 glycoprotein; Zn alpha 2 GP; Zn alpha2 glycoprotein; Zn-alpha-2-glycoprotein; Zn-alpha-2-GP; ZNGP1;

Immunogens

Immunogen:
Uniprot:

P25311(ZA2G_HUMAN) >>Visit HPA database.

Gene(ID):
AZGP1(563)
Expression:
P25311 ZA2G_HUMAN:

Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver.

Description:
Zinc-alpha-2-glycoprotein (AZGP1) is a soluble protein normally found in body fluids, functions as a lipid mobilizing factor (PMID: 19188554). It is known to be expressed in the secretory epithelia of the liver, lung, breast, GI tract and sweat glands, sharing significant structural similarity with the class I major histocompatibility complex (MHC) antigens (PMID: 3422450). AZGP1 is involved in carcinogenesis and differentiation. Altered expression of AZGP1 has been reported in breast cancer, prostate cancer and lung adenocarcinoma, hepatocellular carcinoma, pancreatic carcinoma and oral tumors (PMID: 22625427).
Sequence:
MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFRYNSKDRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSNGSHVLQGRFGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRAKAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHWTRAGEVQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPWEAS

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
82
Horse
73
Bovine
73
Sheep
73
Dog
64
Pig
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P25311 As Substrate

Site PTM Type Enzyme
Y107 Phosphorylation
N109 N-Glycosylation
N112 N-Glycosylation
N128 N-Glycosylation
N259 N-Glycosylation

Research Backgrounds

Function:

Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.

PTMs:

N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver.

Subunit Structure:

Interacts with PIP.

Family&Domains:

Belongs to the MHC class I family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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