PSMB2 Antibody - #DF7365
Product: | PSMB2 Antibody |
Catalog: | DF7365 |
Description: | Rabbit polyclonal antibody to PSMB2 |
Application: | WB IHC |
Reactivity: | Human, Mouse, Rat |
Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
Mol.Wt.: | 22kDa; 23kD(Calculated). |
Uniprot: | P49721 |
RRID: | AB_2839303 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF7365, RRID:AB_2839303.
Fold/Unfold
HC7 I; Macropain subunit C7 I; Macropain subunit C7-I; Multicatalytic endopeptidase complex subunit C7 1; Multicatalytic endopeptidase complex subunit C7 I; Multicatalytic endopeptidase complex subunit C7-I; Proteasome (prosome, macropain) subunit beta type 2; Proteasome beta 2 subunit; Proteasome component C7 I; Proteasome component C7-I; Proteasome subunit beta type-2; PSB2_HUMAN; Psmb2;
Immunogens
A synthesized peptide derived from human PSMB2, corresponding to a region within the internal amino acids.
- P49721 PSB2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
Research Backgrounds
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Cytoplasm. Nucleus.
Belongs to the peptidase T1B family.
Research Fields
· Genetic Information Processing > Folding, sorting and degradation > Proteasome.
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