CD180 Antibody - #DF2294
| Product: | CD180 Antibody |
| Catalog: | DF2294 |
| Description: | Rabbit polyclonal antibody to CD180 |
| Application: | WB IHC |
| Reactivity: | Human |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 90 kDa; 74kD(Calculated). |
| Uniprot: | Q99467 |
| RRID: | AB_2839520 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2294, RRID:AB_2839520.
Fold/Unfold
CD180; CD180 antigen; CD180_HUMAN; F630107B15; LY64; Ly78; Lymphocyte antigen 64; lymphocyte antigen 64 radioprotective 105kDa; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; Radioprotective 105 kDa protein; RP105;
Immunogens
Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
- Q99467 CD180_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAFDVSCFFWVVLFSAGCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKLSCGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQHI
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q99467 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N78 | N-Glycosylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| N402 | N-Glycosylation | Uniprot | |
| T430 | Phosphorylation | Uniprot | |
| N451 | N-Glycosylation | Uniprot |
Research Backgrounds
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).
Cell membrane>Single-pass type I membrane protein.
Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
M-shaped tetramer of two CD180-LY86 heterodimers.
Belongs to the Toll-like receptor family.
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