CD209 Antibody - #DF2295
| Product: | CD209 Antibody |
| Catalog: | DF2295 |
| Description: | Rabbit polyclonal antibody to CD209 |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Rabbit |
| Mol.Wt.: | 44 kDa; 46kD(Calculated). |
| Uniprot: | Q9NNX6 |
| RRID: | AB_2839521 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2295, RRID:AB_2839521.
Fold/Unfold
C type lectin domain family 4 member L; C-type lectin domain family 4 member L; CD 209; CD209; CD209 antigen; CD209 antigen-like protein A; CD209 molecule; CD209_HUMAN; Cd209a; CDSIGN; CIRE; CLEC4L; DC SIGN; DC SIGN1; DC-SIGN; DC-SIGN1; DCSIGN; Dendritic cell specific ICAM 3 grabbing nonintegrin 1; Dendritic cell specific ICAM3 grabbing nonintegrin 1; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; Dengue fever, protection against, included; Dentritic Cell Specific ICAM3 Grabbing Nonintegrin; HIV GP120 Binding Protein; MGC129965; MGC130443; SIGN-R1; SIGNR5;
Immunogens
A synthesized peptide derived from human CD209, corresponding to a region within C-terminal amino acids.
Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.
- Q9NNX6 CD209_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLLVQVSKVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTWLKAAVGELPEKSKMQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTQLKAAVERLCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASCSRDEEQFLSPAPATPNPPPA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
Research Backgrounds
Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.
On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
(Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2.
(Microbial infection) Acts as an attachment receptor for Ebolavirus.
(Microbial infection) Acts as an attachment receptor for Cytomegalovirus.
(Microbial infection) Acts as an attachment receptor for HCV.
(Microbial infection) Acts as an attachment receptor for Dengue virus.
(Microbial infection) Acts as an attachment receptor for Measles virus.
(Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1.
(Microbial infection) Acts as an attachment receptor for Influenzavirus A.
(Microbial infection) Acts as an attachment receptor for SARS coronavirus.
(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.
(Microbial infection) Acts as an attachment receptor for Lassa virus. Acts as an attachment receptor for Marburg virusn.
(Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus.
(Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus.
(Microbial infection) Acts as an attachment receptor for West-nile virus.
(Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule.
Cell membrane>Single-pass type II membrane protein.
Cell membrane>Single-pass type II membrane protein.
Cell membrane>Single-pass type II membrane protein.
Cell membrane>Single-pass type II membrane protein.
Cell membrane>Single-pass type II membrane protein.
Secreted.
Secreted.
Secreted.
Secreted.
Secreted.
Secreted.
Secreted.
Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.
The tandem repeat domain, also called neck domain, mediates oligomerization.
Research Fields
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Human Diseases > Infectious diseases: Viral > Measles.
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