CD97 Antibody - #DF2307
| Product: | CD97 Antibody |
| Catalog: | DF2307 |
| Description: | Rabbit polyclonal antibody to CD97 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Mol.Wt.: | 92 kDa; 92kD(Calculated). |
| Uniprot: | P48960 |
| RRID: | AB_2839531 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2307, RRID:AB_2839531.
Fold/Unfold
ADGRE5; Adhesion G protein-coupled receptor E5; CD 97; CD_antigen=CD97; CD97; CD97 antigen; CD97 antigen subunit beta; CD97 molecule; CD97_HUMAN; Leukocyte antigen CD97; Seven span transmembrane protein; Seven transmembrane helix receptor; Seven transmembrane heterodimeric receptor associated with inflammation; TM7LN 1; TM7LN1;
Immunogens
Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid.
- P48960 CD97_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASESGI
PTMs - P48960 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K281 | Ubiquitination | Uniprot | |
| N371 | N-Glycosylation | Uniprot | |
| T373 | Phosphorylation | Uniprot | |
| S377 | Phosphorylation | Uniprot | |
| S378 | Phosphorylation | Uniprot | |
| Y430 | Phosphorylation | Uniprot | |
| N453 | N-Glycosylation | Uniprot | |
| S531 | Phosphorylation | Uniprot | |
| Y540 | Phosphorylation | Uniprot | |
| K730 | Ubiquitination | Uniprot | |
| K809 | Ubiquitination | Uniprot | |
| Y810 | Phosphorylation | Uniprot | |
| S811 | Phosphorylation | Uniprot | |
| T814 | Phosphorylation | Uniprot | |
| S815 | Phosphorylation | Uniprot | |
| T816 | Phosphorylation | Uniprot | |
| T817 | Phosphorylation | Uniprot | |
| S818 | Phosphorylation | Uniprot | |
| T820 | Phosphorylation | Uniprot | |
| T825 | Phosphorylation | Uniprot | |
| S831 | Phosphorylation | Uniprot | |
| S833 | Phosphorylation | Uniprot |
Research Backgrounds
Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity).
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
Cell membrane>Multi-pass membrane protein.
Secreted>Extracellular space.
Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid.
Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) interacts with chondroitin sulfate.
The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region.
Binding to chondroitin sulfate is mediated by the fourth EGF domain.
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
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