CENPL Antibody - #DF2313
| Product: | CENPL Antibody |
| Catalog: | DF2313 |
| Description: | Rabbit polyclonal antibody to CENPL |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 39 kDa; 39kD(Calculated). |
| Uniprot: | Q8N0S6 |
| RRID: | AB_2839537 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2313, RRID:AB_2839537.
Fold/Unfold
C1orf155; CENP-L; CENPL; CENPL_HUMAN; Centromere protein L; dJ383J4.3; FLJ31044; FLJ31786; Interphase centromere complex protein 33; OTTHUMP00000032689; OTTHUMP00000032690; OTTHUMP00000032691; RP3-383J4.1;
Immunogens
- Q8N0S6 CENPL_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSYSAPESTPSASSRPEDYFIGATPLQKRLESVRKQSSFILTPPRRKIPQCSQLQEDVDPQKVAFLLHKQWTLYSLTPLYKFSYSNLKEYSRLLNAFIVAEKQKGLAVEVGEDFNIKVIFSTLLGMKGTQRDPEAFLVQIVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSEDFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMDHYVATTEFLWSVPCSPQSLDISFAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFKIHLSATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYLTELAIFQIE
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8N0S6 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| T43 | Phosphorylation | Uniprot | |
| K48 | Ubiquitination | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| K144 | Ubiquitination | Uniprot | |
| S310 | Phosphorylation | Uniprot |
Research Backgrounds
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Nucleus. Chromosome>Centromere.
Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.
Belongs to the CENP-L/IML3 family.
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