GZMM Antibody - #DF2378
| Product: | GZMM Antibody |
| Catalog: | DF2378 |
| Description: | Rabbit polyclonal antibody to GZMM |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Prediction: | Chicken |
| Mol.Wt.: | 28 kDa; 28kD(Calculated). |
| Uniprot: | P51124 |
| RRID: | AB_2839586 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2378, RRID:AB_2839586.
Fold/Unfold
GRAM_HUMAN; Granzyme M (lymphocyte met ase 1); Granzyme M; GranzymeM; GZM M; Gzmm; HU Met 1; HU-Met-1; LMET 1; LMET1; Lymphocyte met ase 1; MET 1; Met 1 serine protease; Met ase; Met-1 serine protease; Met-ase; MET1; Met1 serine protease; Natural killer cell granular protease;
Immunogens
- P51124 GRAM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLARVLSFSSRVCTDIFKPPVATAVAPYVSWIRKVTGRSA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P51124 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S17 | Phosphorylation | Uniprot | |
| T83 | Phosphorylation | Uniprot | |
| S187 | Phosphorylation | Uniprot | |
| S224 | Phosphorylation | Uniprot | |
| S226 | Phosphorylation | Uniprot |
Research Backgrounds
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
Secreted. Cytoplasmic granule.
Note: Granules of large granular lymphocytes.
Highly and constitutively expressed in activated natural killer (NK) cells.
Belongs to the peptidase S1 family. Granzyme subfamily.
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