TBR1 Antibody - #DF2396
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| Product: | TBR1 Antibody |
| Catalog: | DF2396 |
| Description: | Rabbit polyclonal antibody to TBR1 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 74 kDa; 74kD(Calculated). |
| Uniprot: | Q16650 |
| RRID: | AB_2839603 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2396, RRID:AB_2839603.
Fold/Unfold
T box brain 1; T box brain protein 1; T brain 1 protein; T-box brain protein 1; T-brain-1; TBR 1; TBR-1; Tbr1; TBR1_HUMAN; TES 56; TES-56;
Immunogens
- Q16650 TBR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPGQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGTKSGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLPPGAAEDAKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDISGYYGFYSHS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16650 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S74 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| S84 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| T408 | Phosphorylation | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| Y425 | Phosphorylation | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| Y440 | Phosphorylation | Uniprot | |
| S480 | Phosphorylation | Uniprot | |
| S549 | Phosphorylation | Uniprot | |
| S594 | Phosphorylation | Uniprot | |
| S610 | Phosphorylation | Uniprot | |
| S613 | Phosphorylation | Uniprot | |
| S623 | Phosphorylation | Uniprot | |
| S629 | Phosphorylation | Uniprot | |
| Y632 | Phosphorylation | Uniprot | |
| S641 | Phosphorylation | Uniprot | |
| S652 | Phosphorylation | Uniprot | |
| S656 | Phosphorylation | Uniprot | |
| K666 | Ubiquitination | Uniprot |
Research Backgrounds
Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity).
Nucleus.
Brain.
Homodimer. Part of a complex containing CASK, TBR1 and TSPYL2; may modulate gene expression in response to neuronal synaptic activity (By similarity). Interacts with FOXP2. Interacts with FOXP1. Interacts with BCL11A.
References
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