HEXIM2 Antibody - #DF2448
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2448, RRID:AB_2839654.
Fold/Unfold
Hexamethylene bis-acetamide-inducible protein 2; Hexamthylene bis-acetamide inducible 2; HEXI2_HUMAN; hexim 2; HEXIM2; L3; Protein HEXIM2;
Immunogens
Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.
- Q96MH2 HEXI2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMATPNQTACNAESPVALEEAKTSGAPGSPQTPPERHDSGGSLPLTPRMESHSEDEDLAGAVGGLGWNSRSPRTQSPGGCSAEAVLARKKHRRRPSKRKRHWRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPEEPNLDVPHGISHPGSSGESEAGDSDGRGRAHGEFQRKDFSETYERFHTESLQGRSKQELVRDYLELEKRLSQAEEETRRLQQLQACTGQQSCRQVEELAAEVQRLRTENQRLRQENQMWNREGCRCDEEPGT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96MH2 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T4 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| T23 | Phosphorylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| T32 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| T46 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| T74 | Phosphorylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| K89 | Acetylation | Uniprot | |
| K90 | Acetylation | Uniprot | |
| S165 | Phosphorylation | Uniprot | |
| S169 | Phosphorylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| R199 | Methylation | Uniprot | |
| R215 | Methylation | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| R223 | Methylation | Uniprot | |
| S225 | Phosphorylation | Uniprot |
Research Backgrounds
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Nucleus.
Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.
Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with CCNT2.
The coiled-coil domain mediates oligomerization.
Belongs to the HEXIM family.
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