BACH2 Antibody - #DF2461
| Product: | BACH2 Antibody |
| Catalog: | DF2461 |
| Description: | Rabbit polyclonal antibody to BACH2 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| Mol.Wt.: | 150kD; 93kD(Calculated). |
| Uniprot: | Q9BYV9 |
| RRID: | AB_2839667 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2461, RRID:AB_2839667.
Fold/Unfold
Bach 2; Bach2; BACH2_HUMAN; Basic leucine zipper transcription factor 2; BTB and CNC homolog 2; BTB and CNC homology 1 basic leucine zipper transcription factor 2; BTB domain and CNC homolog 2; BTBD25; OTTHUMP00000016867; OTTHUMP00000016868; OTTHUMP00000040591; Transcription regulator protein BACH2;
Immunogens
- Q9BYV9 BACH2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSVDEKPDSPMYVYESTVHCTNILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKNDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNSEDGLFVCRKDAACQRPHEDCENSAGEEEDEEEETMDSETAKMACPRDQMLPEPISFEAAAIPVAEKEEALLPEPDVPTDTKESSEKDALTQYPRYKKYQLACTKNVYNASSHSTSGFASTFREDNSSNSLKPGLARGQIKSEPPSEENEEESITLCLSGDEPDAKDRAGDVEMDRKQPSPAPTPTAPAGAACLERSRSVASPSCLRSLFSITKSVELSGLPSTSQQHFARSPACPFDKGITQGDLKTDYTPFTGNYGQPHVGQKEVSNFTMGSPLRGPGLEALCKQEGELDRRSVIFSSSACDQVSTSVHSYSGVSSLDKDLSEPVPKGLWVGAGQSLPSSQAYSHGGLMADHLPGRMRPNTSCPVPIKVCPRSPPLETRTRTSSSCSSYSYAEDGSGGSPCSLPLCEFSSSPCSQGARFLATEHQEPGLMGDGMYNQVRPQIKCEQSYGTNSSDESGSFSEADSESCPVQDRGQEVKLPFPVDQITDLPRNDFQMMIKMHKLTSEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNQLKACMGELLDNFSCLSQEVCRDIQSPEQIQALHRYCPVLRPMDLPTASSINPAPLGAEQNIAASQCAVGENVPCCLEPGAAPPGPPWAPSNTSENCTSGRRLEGTDPGTFSERGPPLEPRSQTVTVDFCQEMTDKCTTDEQPRKDYT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BYV9 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S159 | Phosphorylation | Uniprot | |
| K202 | Sumoylation | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| K276 | Sumoylation | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| S315 | Phosphorylation | Uniprot | |
| T319 | Phosphorylation | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| S350 | Phosphorylation | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| K400 | Ubiquitination | Uniprot | |
| S409 | Phosphorylation | Uniprot | |
| K421 | Sumoylation | Uniprot | |
| S510 | Phosphorylation | Uniprot | |
| S520 | Phosphorylation | Uniprot | |
| S521 | Phosphorylation | P23443 (RPS6KB1) | Uniprot |
| S525 | Phosphorylation | Uniprot | |
| S527 | Phosphorylation | Uniprot | |
| S546 | Phosphorylation | Uniprot | |
| S551 | Phosphorylation | Uniprot | |
| Y572 | Phosphorylation | Uniprot | |
| K580 | Sumoylation | Uniprot |
Research Backgrounds
Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation.
Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.
The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses.
Cytoplasm. Nucleus.
Note: Nucleocytoplasmic shuttling is controlled by phosphorylation.
B-cell specific.
Homodimer; disulfide-linked. Heterodimer of BACH2 and Maf-related transcription factors (By similarity).
Belongs to the bZIP family. CNC subfamily.
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