TRI31 Antibody - #DF2463

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Product: TRI31 Antibody
Catalog: DF2463
Description: Rabbit polyclonal antibody to TRI31
Application: WB IHC IF/ICC
Reactivity: Human
Mol.Wt.: 48kDa; 48kD(Calculated).
Uniprot: Q9BZY9
RRID: AB_2839669

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
TRI31 Antibody detects endogenous levels of total TRI31.
RRID:
AB_2839669
Cite Format: Affinity Biosciences Cat# DF2463, RRID:AB_2839669.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

C6orf13; H.sapiens mRNA for RING protein; HCG1; HCGI; Ring finger protein; RNF; Tripartite motif containing protein 31;

Immunogens

Immunogen:
Uniprot:

Q9BZY9(TRI31_HUMAN) >>Visit HPA database.

Gene(ID):
TRIM31(11074)
Expression:
Q9BZY9 TRI31_HUMAN:

Up-regulated in gastric adenocarcinomas.

Sequence:
MASGQFVNKLQEEVICPICLDILQKPVTIDCGHNFCLKCITQIGETSCGFFKCPLCKTSVRKNAIRFNSLLRNLVEKIQALQASEVQSKRKEATCPRHQEMFHYFCEDDGKFLCFVCRESKDHKSHNVSLIEEAAQNYQGQIQEQIQVLQQKEKETVQVKAQGVHRVDVFTDQVEHEKQRILTEFELLHQVLEEEKNFLLSRIYWLGHEGTEAGKHYVASTEPQLNDLKKLVDSLKTKQNMPPRQLLEDIKVVLCRSEEFQFLNPTPVPLELEKKLSEAKSRHDSITGSLKKFKDQLQADRKKDENRFFKSMNKNDMKSWGLLQKNNHKMNKTSEPGSSSAGGRTTSGPPNHHSSAPSHSLFRASSAGKVTFPVCLLASYDEISGQGASSQDTKTFDVALSEELHAALSEWLTAIRAWFCEVPSS

PTMs - Q9BZY9 As Substrate

Site PTM Type Enzyme
T333 Phosphorylation
S339 Phosphorylation
S340 Phosphorylation

Research Backgrounds

Function:

Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.

PTMs:

Auto-ubiquitinated (in vitro).

Subcellular Location:

Cytoplasm. Mitochondrion.
Note: Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Up-regulated in gastric adenocarcinomas.

Subunit Structure:

Interacts with isoform p52shc of SHC1 (By similarity). May form oligomers.

Family&Domains:

Belongs to the TRIM/RBCC family.

References

1). Genome-Wide CRISPR/Cas9 Screening Identifies That Mitochondrial Solute Carrier SLC25A23 Attenuates Type I IFN Antiviral Immunity via Interfering with MAVS Aggregation. Journal of immunology (Baltimore, Md. : 1950), 2023 (PubMed: 37695673) [IF=3.6]

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