TSYL2 Antibody - #DF2466

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Product: TSYL2 Antibody
Catalog: DF2466
Description: Rabbit polyclonal antibody to TSYL2
Application: WB IHC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 79kDa; 79kD(Calculated).
Uniprot: Q9H2G4
RRID: AB_2839672

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
TSYL2 Antibody detects endogenous levels of total TSYL2.
RRID:
AB_2839672
Cite Format: Affinity Biosciences Cat# DF2466, RRID:AB_2839672.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

CASK interacting nucleosome assembly protein; CDA1; Cell division autoantigen 1; CINAP; CTCL; CTCL tumor antigen se20 4; CTCL-associated antigen se20-4; Cutaneous T cell lymphoma associated antigen se20 4; Cutaneous T cell lymphoma associated tumor antigen se20 4; Cutaneous T-cell lymphoma-associated antigen se20-4; Differentially Expressed Nucleolar TGF beta1 Target; Differentially Expressed Nucleolar TGF beta1 Target protein; Differentially-expressed nucleolar TGF-beta1 target protein; HRIHFB2216; NP79; Nuclear protein of 79 kDa; RP1 290F12.2; SE20 4; SE204; Testis specific protein Y encoded like 2; testis-specific protein Y encoded-like 2; Testis-specific Y-encoded-like protein 2; TSPX; TSPY like 2; TSPY like protein 2; TSPY-like protein 2; TSPYL2; TSYL2_HUMAN;

Immunogens

Immunogen:
Uniprot:

Q9H2G4(TSYL2_HUMAN) >>Visit HPA database.

Gene(ID):
TSPYL2(64061)
Expression:
Q9H2G4 TSYL2_HUMAN:

Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.

Sequence:
MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLADMRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPTPEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDERESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRLKRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLRHISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSENPDHNEVPNNETTDNNESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYGNNFFKGGFWGSHGNNQDSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDDRDIEYYEKVIEDFDKDQADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSEDVWEEGEDSDDSDLEDVLQVPNGWANPGKRGKTG

PTMs - Q9H2G4 As Substrate

Site PTM Type Enzyme
K11 Ubiquitination
S16 Phosphorylation
S17 Phosphorylation
S18 Phosphorylation
S20 Phosphorylation P24941 (CDK2)
S182 Phosphorylation
K235 Ubiquitination
S303 Phosphorylation
Y306 Phosphorylation
Y311 Phosphorylation
S339 Phosphorylation
T340 Phosphorylation P24941 (CDK2)
K384 Ubiquitination
K407 Methylation
K414 Acetylation

Research Backgrounds

Function:

Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.

PTMs:

Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.

Subcellular Location:

Nucleus. Cytoplasm.
Note: Enriched in transcriptionally active regions of chromatin in neurons.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.

Subunit Structure:

Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TBR1 and TSPYL2 (By similarity).

Family&Domains:

Belongs to the nucleosome assembly protein (NAP) family.

Restrictive clause

 

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