MIB2 Antibody - #DF2583
| Product: | MIB2 Antibody |
| Catalog: | DF2583 |
| Description: | Rabbit polyclonal antibody to MIB2 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Dog, Chicken |
| Mol.Wt.: | 110 kDa; 110kD(Calculated). |
| Uniprot: | Q96AX9 |
| RRID: | AB_2839789 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2583, RRID:AB_2839789.
Fold/Unfold
E3 ubiquitin-protein ligase MIB2; Mib2; Mindbomb homolog 2; Novel zinc finger protein; Novelzin; Putative NF-kappa-B-activating protein 002N; SKD; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1; ZZANK1;
Immunogens
- Q96AX9 MIB2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGWKPSEARGQSQSFQASGLQPRSLKAARRATGRPDRSRAARPTMDPSAHRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSKKLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96AX9 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S24 | Phosphorylation | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| T200 | Phosphorylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K238 | Ubiquitination | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| T260 | Phosphorylation | Uniprot | |
| Y269 | Phosphorylation | Uniprot | |
| K300 | Ubiquitination | Uniprot | |
| S309 | Phosphorylation | Uniprot | |
| S312 | Phosphorylation | Uniprot | |
| K320 | Ubiquitination | Uniprot | |
| K322 | Ubiquitination | Uniprot | |
| T374 | Phosphorylation | Uniprot | |
| T381 | Phosphorylation | Uniprot | |
| K402 | Ubiquitination | Uniprot | |
| K427 | Ubiquitination | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| K689 | Ubiquitination | Uniprot | |
| K842 | Methylation | Uniprot | |
| K842 | Ubiquitination | Uniprot |
Research Backgrounds
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Ubiquitinated. Possibly via autoubiquitination (By similarity).
Cytoplasm. Endosome.
Note: Colocalizes with endosomal compartments.
Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.
Interacts with actin monomer.
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