MUL1 Antibody - #DF2589
| Product: | MUL1 Antibody |
| Catalog: | DF2589 |
| Description: | Rabbit polyclonal antibody to MUL1 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Rabbit, Dog |
| Mol.Wt.: | 38 kDa; 40kD(Calculated). |
| Uniprot: | Q969V5 |
| RRID: | AB_2839795 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2589, RRID:AB_2839795.
Fold/Unfold
0610009K11Rik; AV000801; C1orf166; Chromosome 1 open reading frame 166; E3 SUMO-protein ligase MUL1; E3 ubiquitin ligase; E3 ubiquitin protein ligase MUL1; E3 ubiquitin-protein ligase MUL1; FLJ12875; GIDE; Growth inhibition and death E3 ligase; MAPL; Mitochondrial anchored protein ligase; mitochondrial E3 ubiquitin ligase 1; mitochondrial E3 ubiquitin protein ligase 1; Mitochondrial ubiquitin ligase activator of NFKB 1; Mitochondrial-anchored protein ligase; MUL1; MUL1_HUMAN; MULAN; Putative NF kappa B activating protein 266; Putative NF-kappa-B-activating protein 266; RGD1309944; RING finger protein 218; RNF218; RP11-401M16.2; RP23-25C1.10-002;
Immunogens
Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus.
- Q969V5 MUL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MESGGRPSLCQFILLGTTSVVTAALYSVYRQKARVSQELKGAKKVHLGEDLKSILSEAPGKCVPYAVIEGAVRSVKETLNSQFVENCKGVIQRLTLQEHKMVWNRTTHLWNDCSKIIHQRTNTVPFDLVPHEDGVDVAVRVLKPLDSVDLGLETVYEKFHPSIQSFTDVIGHYISGERPKGIQETEEMLKVGATLTGVGELVLDNNSVRLQPPKQGMQYYLSSQDFDSLLQRQESSVRLWKVLALVFGFATCATLFFILRKQYLQRQERLRLKQMQEEFQEHEAQLLSRAKPEDRESLKSACVVCLSSFKSCVFLECGHVCSCTECYRALPEPKKCPICRQAITRVIPLYNS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q969V5 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Ubiquitination | Uniprot | ||
| S3 | Phosphorylation | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| K76 | Ubiquitination | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| Y156 | Phosphorylation | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| K299 | Ubiquitination | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| Y350 | Phosphorylation | Uniprot |
Research Backgrounds
Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization. Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway. May also be involved in the sumoylation of the membrane fission protein DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Mitochondrion outer membrane>Multi-pass membrane protein. Peroxisome.
Note: Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome.
Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus.
Homooligomer. Interacts with MAP3K7/TAK1. Interacts with UBC9. Interacts with MAVS.
The zinc finger domain is required for E3 ligase activity.
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