ZDHHC17 Antibody - #DF2601
| Product: | ZDHHC17 Antibody |
| Catalog: | DF2601 |
| Description: | Rabbit polyclonal antibody to ZDHHC17 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 73 kDa; 73kD(Calculated). |
| Uniprot: | Q8IUH5 |
| RRID: | AB_2839807 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2601, RRID:AB_2839807.
Fold/Unfold
DHHC 17; DHHC domain containing 17; HIP14; HIP3; HSPC294; huntingtin interacting protein 14; huntingtin interacting protein 3; Huntingtin interacting protein H; HYPH; KIAA0946; Putative MAPK activating protein PM11; Putative NF kappa B activating protein 205; ZDHHC 17; zinc finger; Zinc finger DHHC domain containing 17; Zinc finger DHHC domain containing protein 17; Zinc finger DHHC type containing 17;
Immunogens
Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney.
- Q8IUH5 ZDH17_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQREEGFNTKMADGPDEYDTEAGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8IUH5 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y39 | Phosphorylation | Uniprot | |
| Y43 | Phosphorylation | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| Y56 | Phosphorylation | Uniprot | |
| Y67 | Phosphorylation | Uniprot | |
| Y70 | Phosphorylation | Uniprot | |
| Y81 | Phosphorylation | Uniprot | |
| R84 | Methylation | Uniprot | |
| T192 | Phosphorylation | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| Y286 | Phosphorylation | Uniprot | |
| K296 | Methylation | Uniprot | |
| K299 | Methylation | Uniprot | |
| S346 | Phosphorylation | Uniprot | |
| K462 | Acetylation | Uniprot | |
| S502 | Phosphorylation | Uniprot | |
| Y503 | Phosphorylation | Uniprot | |
| Y629 | Phosphorylation | Uniprot |
Research Backgrounds
Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg(2+) transport.
Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport.
Golgi apparatus membrane>Multi-pass membrane protein. Cytoplasmic vesicle membrane>Multi-pass membrane protein. Cell junction>Synapse>Presynaptic cell membrane>Multi-pass membrane protein.
Note: Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles.
Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney.
Interacts (via ANK repeats) with numerous proteins (via the consensus sequence motif [VIAP]-[VIT]-x-x-Q-P). Interacts (via ANK repeats) with CLIP3. Interacts (via ANK repeats) with HTT; this interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease. Interacts (via ANK repeats) with DNAJC5 (via C-terminus). Interacts (via ANK repeats) with MAP6. Interacts (via ANK repeats) with SNAP23. Interacts (via ANK repeats) with SNAP25. Interacts (via ANK repeats) with EVL. May interact (via ANK repeats) with SPRED2 (By similarity).
The DHHC domain is required for palmitoyltransferase activity.
Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
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