TTBK1 Antibody - #DF2687
| Product: | TTBK1 Antibody |
| Catalog: | DF2687 |
| Description: | Rabbit polyclonal antibody to TTBK1 |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 143 kDa; 143kD(Calculated). |
| Uniprot: | Q5TCY1 |
| RRID: | AB_2839893 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2687, RRID:AB_2839893.
Fold/Unfold
BDTK; Brain derived tau kinase; Brain-derived tau kinase; KIAA1855; Tau tubulin kinase 1; Tau-tubulin kinase 1; TTBK1; TTBK1_HUMAN;
Immunogens
Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.
- Q5TCY1 TTBK1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQCLAAALKDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQTAAMFGVVNVTPVPGDLLRENTEDVLQGEHLSDQENAPPILPGRPSEGLGPSPHLVPHPGGPEAEVWEETDVNRNKLRINIGKSPCVEEEQSRGMGVPSSPVRAPPDSPTTPVRSLRYRRVNSPESERLSTADGRVELPERRSRMDLPGSPSRQACSSQPAQMLSVDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDSKEWVIIDKETELKDFPPGAEPSTSGTTDEEPEELRPLPEEGEERRRLGAEPTVRPRGRSMQALAEEDLQHLPPQPLPPQLSQGDGRSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQRQVFSVAPPFEVNGLPRAVPLSLPYQDFKRDLSDYRERARLLNRVRRVGFSHMLLTTPQVPLAPVQPQANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGEVLGPRSGSSSEGSERSTDRSQEGAPSTLLADDQKESRGRASMADGDLEPEEGSKTLVLVSPGDMKKSPVTAELAPDPDLGTLAALTPQHERPQPTGSQLDVSEPGTLSSVLKSEPKPPGPGAGLGAGTVTTGVGGVAVTSSPFTKVERTFVHIAEKTHLNVMSSGGQALRSEEFSAGGELGLELASDGGAVEEGARAPLENGLALSGLNGAEIEGSALSGAPRETPSEMATNSLPNGPALADGPAPVSPLEPSPEKVATISPRRHAMPGSRPRSRIPVLLSEEDTGSEPSGSLSAKERWSKRARPQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPAAALPRKSGRAAATRSRIPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSRLQLQTPPGSATAADLRPKQPPGRGLGPGRAQAGARPPAPRSPRLPASTSAARNASASPRSQSLSRRESPSPSHQARPGVPPPRGVPPARAQPDGTPSPGGSKKGPRGKLQAQRATTKGRAGGAEGRAGAR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q5TCY1 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T12 | Phosphorylation | Uniprot | |
| K75 | Acetylation | Uniprot | |
| K83 | Sumoylation | Uniprot | |
| Y169 | Phosphorylation | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| S433 | Phosphorylation | Uniprot | |
| S456 | Phosphorylation | Uniprot | |
| S459 | Phosphorylation | Uniprot | |
| S463 | Phosphorylation | Uniprot | |
| T464 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot | |
| T629 | Phosphorylation | Uniprot | |
| S630 | Phosphorylation | Uniprot | |
| S693 | Phosphorylation | Uniprot | |
| Y695 | Phosphorylation | Uniprot | |
| S790 | Phosphorylation | Uniprot | |
| S943 | Phosphorylation | Uniprot | |
| S944 | Phosphorylation | Uniprot | |
| S1041 | Phosphorylation | Uniprot | |
| T1152 | Phosphorylation | Uniprot | |
| S1200 | Phosphorylation | Uniprot | |
| T1202 | Phosphorylation | Uniprot | |
| S1232 | Phosphorylation | Uniprot | |
| S1246 | Phosphorylation | Uniprot | |
| S1248 | Phosphorylation | Uniprot | |
| S1253 | Phosphorylation | Uniprot | |
| S1259 | Phosphorylation | Uniprot |
PTMs - Q5TCY1 As Enzyme
| Substrate | Site | Source |
|---|---|---|
| P07437 (TUBB) | S275 | Uniprot |
| P10636-8 (MAPT) | Y197 | Uniprot |
| P10636-8 (MAPT) | S198 | Uniprot |
| P10636-8 (MAPT) | S199 | Uniprot |
| P10636-8 (MAPT) | S202 | Uniprot |
| P10636-8 (MAPT) | S416 | Uniprot |
| P10636-8 (MAPT) | S422 | Uniprot |
| P10636-8 (MAPT) | T427 | Uniprot |
| P10636 (MAPT) | S515 | Uniprot |
| P10636 (MAPT) | S516 | Uniprot |
| P10636 (MAPT) | S519 | Uniprot |
| P10636 (MAPT) | S739 | Uniprot |
| Q13885 (TUBB2A) | S275 | Uniprot |
Research Backgrounds
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.
Cytoplasm.
Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.