GPR61 Antibody - #DF2755
| Product: | GPR61 Antibody |
| Catalog: | DF2755 |
| Description: | Rabbit polyclonal antibody to GPR61 |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse |
| Mol.Wt.: | 49 kDa; 49kD(Calculated). |
| Uniprot: | Q9BZJ8 |
| RRID: | AB_2839961 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2755, RRID:AB_2839961.
Fold/Unfold
BALGR; Biogenic amine receptor like G protein coupled receptor; Biogenic amine receptor-like G-protein coupled receptor; G protein coupled receptor 61; GPCR3; Gpr61; GPR61_HUMAN; Probable G-protein coupled receptor 61;
Immunogens
Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus (PubMed:11690637, PubMed:29226084). Also expressed in testis (PubMed:11690637, PubMed:29226084) and T cells, B cells, and monocyte (PubMed:29226084). Low expression in many other tissues (PubMed:11690637, PubMed:29226084). Widely expressed in the hippocampus (at protein level).
- Q9BZJ8 GPR61_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAASPRLES
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BZJ8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N12 | N-Glycosylation | Uniprot | |
| S161 | Phosphorylation | Uniprot |
Research Backgrounds
Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization. May be involved in the regulation of food intake and body weight (By similarity).
Cell membrane>Multi-pass membrane protein. Endosome membrane>Multi-pass membrane protein.
Note: Colocalizes with ARRB2/beta-arrestin-2 in the endosome (PubMed:28827538).
Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus. Also expressed in testis and T cells, B cells, and monocyte. Low expression in many other tissues. Widely expressed in the hippocampus (at protein level).
Forms heterodimer with MTNR1B. Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR61 in the endosomal compartment.
Belongs to the G-protein coupled receptor 1 family.
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