GPR62 Antibody - #DF2756
| Product: | GPR62 Antibody |
| Catalog: | DF2756 |
| Description: | Rabbit polyclonal antibody to GPR62 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Horse |
| Mol.Wt.: | 38 kDa; 38kD(Calculated). |
| Uniprot: | Q9BZJ7 |
| RRID: | AB_2839962 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2756, RRID:AB_2839962.
Fold/Unfold
G protein coupled receptor GPCR8; G protein coupled receptor KPG_005; G protein-coupled receptor 62; G-protein coupled receptor GPCR8; G-protein coupled receptor KPG_005; GPCR8; GPR62; GPR62_HUMAN; hGPCR8; KPG_005; MGC26943; Probable G protein coupled receptor 62; Probable G-protein coupled receptor 62;
Immunogens
Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.
- Q9BZJ7 GPR62_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MANSTGLNASEVAGSLGLILAAVVEVGALLGNGALLVVVLRTPGLRDALYLAHLCVVDLLAAASIMPLGLLAAPPPGLGRVRLGPAPCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGSRPPPVLVLTAVWAAAGLLGALSLLGTPPAPPPAPARCSVLAGGLGPFRPLWALLAFALPALLLLGAYGGIFVVARRAALRPPRPARGSRLHSDSLDSRLSILPPLRPRLPGGKAALAPALAVGQFAACWLPYGCACLAPAARAAEAEAAVTWVAYSAFAAHPFLYGLLQRPVRLALGRLSRRALPGPVRACTPQAWHPRALLQCLQRPPEGPAVGPSEAPEQTPELAGGRSPAYQGPPESSLS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
Research Backgrounds
Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways. Has spontaneous activity for beta-arrestin recruitment. Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization.
Cell membrane>Multi-pass membrane protein. Endosome membrane>Multi-pass membrane protein.
Note: Colocalizes with ARRB2 in the endosome (PubMed:28827538).
Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.
Homodimers (By similarity). Forms heterodimer with MTNR1B. Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR62 in the endosomal compartment.
Lacks the conserved DRY and BBXXB motifs. The restoration of these motifs affects its constitutive activity.
Belongs to the G-protein coupled receptor 1 family.
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