C5ARL Antibody - #DF2762
| Product: | C5ARL Antibody |
| Catalog: | DF2762 |
| Description: | Rabbit polyclonal antibody to C5ARL |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human |
| Prediction: | Pig, Bovine, Sheep, Dog |
| Mol.Wt.: | 36 kDa; 36kD(Calculated). |
| Uniprot: | Q9P296 |
| RRID: | AB_2839968 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2762, RRID:AB_2839968.
Fold/Unfold
C5a anaphylatoxin chemotactic receptor C5L2; C5ARL_HUMAN; C5L2; E030029A11Rik; G protein coupled receptor 77; G protein coupled receptor C5L2; G-protein coupled receptor 77; GPF77; GPR77;
Immunogens
- Q9P296 C5AR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9P296 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S323 | Phosphorylation | Uniprot |
Research Backgrounds
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.
Cell membrane>Multi-pass membrane protein.
Frontal cortex, hippocampus, hypothalamus, pons and liver.
Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.
Belongs to the G-protein coupled receptor 1 family.
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