GPR137B Antibody - #DF2792
| Product: | GPR137B Antibody |
| Catalog: | DF2792 |
| Description: | Rabbit polyclonal antibody to GPR137B |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 46 kDa; 46kD(Calculated). |
| Uniprot: | O60478 |
| RRID: | AB_2839998 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2792, RRID:AB_2839998.
Fold/Unfold
G protein-coupled receptor 137B; GPR137B; integral membrane protein GPR137B; TM7SF1L, included; TM7SF1S, included; transmembrane 7 superfamily member 1 (upregulated in kidney); Transmembrane 7 superfamily member 1; Transmembrane 7 superfamily member 1, long, included; Transmembrane 7 superfamily protein member 1; Transmembrane 7 superfamily protein member 1, short, included;
Immunogens
- O60478 G137B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRPERPRPRGSAPGPMETPPWDPARNDSLPPTLTPAVPPYVKLGLTVVYTVFYALLFVFIYVQLWLVLRYRHKRLSYQSVFLFLCLFWASLRTVLFSFYFKDFVAANSLSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVIFKAKSKYSPELLKYRLPLYLASLFISLVFLLVNLTCAVLVKTGNWERKVIVSVRVAINDTLFVLCAVSLSICLYKISKMSLANIYLESKGSSVCQVTAIGVTVILLYTSRACYNLFILSFSQNKSVHSFDYDWYNVSDQADLKNQLGDAGYVLFGVVLFVWELLPTTLVVYFFRVRNPTKDLTNPGMVPSHGFSPRSYFFDNPRRYDSDDDLAWNIAPQGLQGGFAPDYYDWGQQTNSFLAQAGTLQDSTLDPDKPSLG
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O60478 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T34 | Phosphorylation | Uniprot | |
| Y40 | Phosphorylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| Y77 | Phosphorylation | Uniprot | |
| S79 | Phosphorylation | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| S145 | Phosphorylation | Uniprot | |
| Y147 | Phosphorylation | Uniprot |
Research Backgrounds
Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy.
Acts also as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity).
Lysosome membrane>Multi-pass membrane protein.
Note: Colocalized with MTOR in lysosome after amino acid stimulation.
Expressed in kidney, heart, brain and placenta.
Interaction with RRAGA; increases RRAGA recruitment to lysosomes. Interacts with MTOR; this interaction is amino acid sensitive.
Belongs to the GPR137 family.
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