Product: FOXP1 Antibody
Catalog: BF0028
Description: Mouse monoclonal antibody to FOXP1
Application: WB IHC ELISA FACS
Reactivity: Human
Mol.Wt.: 75.3kDa; 75kD(Calculated).
Uniprot: Q9H334
RRID: AB_2834052

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Product Info

ELISA 1:10000, WB 1:500-1:2000, IHC 1:200-1:1000, FCM 1:200-1:400
*The optimal dilutions should be determined by the end user.

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Monoclonal [AFB2030]
FOXP1 antibody detects endogenous levels of total FOXP1.
Cite Format: Affinity Biosciences Cat# BF0028, RRID:AB_2834052.
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.


12CC4; FLJ23741; Fork head related protein like B; Forkhead box P1; Forkhead box protein P1; FOX P1; FOXP 1; foxp1; FOXP1_HUMAN; Glutamine rich factor 1; hFKH1B; HSPC215; MGC12942; MGC88572; MGC99551; QRF 1; QRF1;



Purified recombinant fragment of human FOXP1 expressed in E. Coli.


Isoform 8 is specifically expressed in embryonic stem cells.

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains.

PTMs - Q9H334 As Substrate

Site PTM Type Enzyme
S79 Phosphorylation
K82 Ubiquitination
S83 Phosphorylation
K149 Ubiquitination
K166 Ubiquitination
T285 Phosphorylation
R336 Methylation
T367 Phosphorylation
K377 Ubiquitination
S440 Phosphorylation
K460 Ubiquitination
K521 Ubiquitination
K543 Ubiquitination
S615 Phosphorylation
S618 Phosphorylation
S620 Phosphorylation
S621 Phosphorylation
S625 Phosphorylation
K636 Sumoylation
S650 Phosphorylation
T653 Phosphorylation
S658 Phosphorylation

Research Backgrounds


Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling. Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA.

Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences). Promotes ESC self-renewal and pluripotency (By similarity).

Subcellular Location:

Note: Not found in the nucleolus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Isoform 8 is specifically expressed in embryonic stem cells.

Subunit Structure:

Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Self-associates. Interacts with CTBP1 (By similarity). Interacts with NCOR2 and AR. Interacts with FOXP2. Interacts with TBR1. Interacts with AURKA; this interaction facilitates the phosphorylation of FOXP1, which suppresses the expression of FBXL7.


The leucine-zipper is required for dimerization and transcriptional repression.

Research Fields

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

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