Product: SFXN4 Antibody
Catalog: AF0580
Description: Rabbit polyclonal antibody to SFXN4
Application: WB IF/ICC
Reactivity: Human
Mol.Wt.: 37kDa; 38kD(Calculated).
Uniprot: Q6P4A7
RRID: AB_2834289

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Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
SFXN4 Antibody detects endogenous levels of total SFXN4.
RRID:
AB_2834289
Cite Format: Affinity Biosciences Cat# AF0580, RRID:AB_2834289.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

BCRM1; Breast cancer resistance marker 1; SFXN 4; Sideroflexin 4;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Description:
Sfxn4 Potential iron transporter. Belongs to the sideroflexin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Sequence:
MSLEQEEETQPGRLLGRRDAVPAFIEPNVRFWITERQSFIRRFLQWTELLDPTNVFISVESIENSRQLLCTNEDVSSPASADQRIQEAWKRSLATVHPDSSNLIPKLFRPAAFLPFMAPTVFLSMTPLKGIKSVILPQVFLCAYMAAFNSINGNRSYTCKPLERSLLMAGAVASSTFLGVIPQFVQMKYGLTGPWIKRLLPVIFLVQASGMNVYMSRSLESIKGIAVMDKEGNVLGHSRIAGTKAVRETLASRIVLFGTSALIPEVFTYFFKRTQYFRKNPGSLWILKLSCTVLAMGLMVPFSFSIFPQIGQIQYCSLEEKIQSPTEETEIFYHRGV

PTMs - Q6P4A7 As Substrate

Site PTM Type Enzyme
S2 Acetylation
S2 Phosphorylation
K90 Ubiquitination
K106 Ubiquitination
C159 S-Nitrosylation
K160 Ubiquitination
K197 Acetylation
K197 Ubiquitination
S209 Phosphorylation
K223 Ubiquitination
K230 Ubiquitination
S324 Phosphorylation

Research Backgrounds

Function:

Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria.

Subcellular Location:

Mitochondrion inner membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Family&Domains:

Belongs to the sideroflexin family.

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