MYBPC3 Antibody - #DF8063
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8063, RRID:AB_2841419.
Fold/Unfold
C protein cardiac muscle isoform; C-protein; cardiac muscle isoform; Cardiac MyBP C; Cardiac MyBP-C; cardiac-type; MYBPC3; myosin binding protein C cardiac; Myosin binding protein C cardiac type; Myosin-binding protein C; MYPC3_HUMAN;
Immunogens
- Q14896 MYPC3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPEPGKKPVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPADQGSYAVIAGSSKVKFDLKVIEAEKAEPMLAPAPAPAEATGAPGEAPAPAAELGESAPSPKGSSSAALNGPTPGAPDDPIGLFVMRPQDGEVTVGGSITFSARVAGASLLKPPVVKWFKGKWVDLSSKVGQHLQLHDSYDRASKVYLFELHITDAQPAFTGSYRCEVSTKDKFDCSNFNLTVHEAMGTGDLDLLSAFRRTSLAGGGRRISDSHEDTGILDFSSLLKKRDSFRTPRDSKLEAPAEEDVWEILRQAPPSEYERIAFQYGVTDLRGMLKRLKGMRRDEKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKCSTELFVKEPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQEKKLEVYQSIADLMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVIWQKAITQGNKAPARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPKISNVGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMRLNFDLIQELSHEARRMIEGVVYEMRVYAVNAIGMSRPSPASQPFMPIGPPSEPTHLAVEDVSDTTVSLKWRPPERVGAGGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPGAPVTTTEPVTVQEILQRPRLQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIRNSPTDTILFIRAARRVHSGTYQVTVRIENMEDKATLVLQVVDKPSPPQDLRVTDAWGLNVALEWKPPQDVGNTELWGYTVQKADKKTMEWFTVLEHYRRTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFIPRPGITYEPPNYKALDFSEAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPCPFDGGIYVCRATNLQGEARCECRLEVRVPQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q14896 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S18 | Phosphorylation | Uniprot | |
| T59 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| Y79 | Phosphorylation | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| S133 | Phosphorylation | P49841 (GSK3B) | Uniprot |
| S212 | Phosphorylation | Uniprot | |
| Y213 | Phosphorylation | Uniprot | |
| T274 | Phosphorylation | Uniprot | |
| S275 | Phosphorylation | P22612 (PRKACG) , Q05655 (PRKCD) , P22694 (PRKACB) , P17612 (PRKACA) | Uniprot |
| S284 | Phosphorylation | P17612 (PRKACA) , P22694 (PRKACB) , Q05655 (PRKCD) , P22612 (PRKACG) | Uniprot |
| S286 | Phosphorylation | Uniprot | |
| T290 | Phosphorylation | Uniprot | |
| S304 | Phosphorylation | P17612 (PRKACA) , P22694 (PRKACB) , Q05655 (PRKCD) , P22612 (PRKACG) , Q15139 (PRKD1) | Uniprot |
| T307 | Phosphorylation | Uniprot | |
| S311 | Phosphorylation | P22694 (PRKACB) , P17612 (PRKACA) , P22612 (PRKACG) | Uniprot |
| Y340 | Phosphorylation | Uniprot | |
| Y373 | Phosphorylation | Uniprot | |
| K418 | Acetylation | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| S427 | Phosphorylation | Uniprot | |
| Y548 | Phosphorylation | Uniprot | |
| S550 | Phosphorylation | Uniprot | |
| S588 | Phosphorylation | Uniprot | |
| T602 | Phosphorylation | Uniprot | |
| T607 | Phosphorylation | Uniprot | |
| S708 | Phosphorylation | Uniprot | |
| S830 | Phosphorylation | Uniprot | |
| Y1043 | Phosphorylation | Uniprot | |
| S1067 | Phosphorylation | Uniprot | |
| Y1119 | Phosphorylation | Uniprot | |
| Y1135 | Phosphorylation | Uniprot | |
| Y1136 | Phosphorylation | Uniprot | |
| Y1167 | Phosphorylation | Uniprot | |
| Y1172 | Phosphorylation | Uniprot | |
| T1237 | Phosphorylation | Uniprot |
Research Backgrounds
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction (By similarity).
Polyubiquitinated.
Belongs to the immunoglobulin superfamily. MyBP family.
Research Fields
· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).
· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).
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