PTGES2 Antibody - #DF12712

(3)  
Product: PTGES2 Antibody
Catalog: DF12712
Description: Rabbit polyclonal antibody to PTGES2
Application: WB IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Dog
Mol.Wt.: 30 kDa; 42kD(Calculated).
Uniprot: Q9H7Z7
RRID: AB_2845673

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
PTGES2 Antibody detects endogenous levels of total PTGES2.
RRID:
AB_2845673
Cite Format: Affinity Biosciences Cat# DF12712, RRID:AB_2845673.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

C9orf15; FLJ14038; Gamma interferon activated transcriptional element binding factor 1; GATE binding factor 1; GBF 1; GBF1; Membrane associated prostaglandin E synthase 2; MGC11289; Microsomal prostaglandin E synthase 2; mPGES 2; mPGES-2; PGES2; PGES2_HUMAN; Prostaglandin E synthase 2; Prostaglandin E synthase 2 truncated form; PTGES 2; PTGES2;

Immunogens

Immunogen:
Uniprot:

Q9H7Z7(PGES2_HUMAN) >>Visit HPA database.

Gene(ID):
PTGES2(80142)
Expression:
Q9H7Z7 PGES2_HUMAN:

Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.

Sequence:
MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLGAAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Dog
100
Chicken
67
Zebrafish
58
Sheep
0
Xenopus
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9H7Z7 As Substrate

Site PTM Type Enzyme
S46 Phosphorylation
K53 Acetylation
T75 Phosphorylation
S90 Phosphorylation
S95 Phosphorylation
S97 Phosphorylation
T109 Phosphorylation
K115 Ubiquitination
Y127 Phosphorylation
K141 Ubiquitination
K147 Ubiquitination
Y188 Phosphorylation
K193 Ubiquitination
K200 Ubiquitination
T203 Phosphorylation
K208 Ubiquitination
Y209 Phosphorylation
K216 Ubiquitination
K225 Ubiquitination
K233 Ubiquitination
S260 Phosphorylation
Y263 Phosphorylation
K269 Ubiquitination
Y280 Phosphorylation
Y287 Phosphorylation
S290 Phosphorylation
Y308 Phosphorylation
K313 Ubiquitination
T371 Phosphorylation
S374 Phosphorylation

Research Backgrounds

Function:

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).

Subcellular Location:

Golgi apparatus membrane>Single-pass membrane protein.

Cytoplasm>Perinuclear region.
Note: Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.

Subunit Structure:

Homodimer. May interact with CEBPB (By similarity). Interacts with EXOSC10.

Family&Domains:

Belongs to the GST superfamily.

Research Fields

· Metabolism > Lipid metabolism > Arachidonic acid metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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